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Genetically modified animals

Development of transgenic models susceptible and resistant to SARS-CoV-2 infection in FVB background mice

Sun-Min Seo, Jae Hyung Son, Ji-Hun Lee, Na-Won Kim, Eun-Seon Yoo, Ah-Reum Kang, Ji Yun Jang, Da In On, Hyun Ah Noh, Jun-Won Yun, Jun Won Park, Kang-Seuk Choi, Ho-Young Lee, Jeon-Soo Shin, Jun-Young Seo, Ki Taek Nam, Ho Lee, Je Kyung Seong, Yang-Kyu Choi

published 26 Jul 2022

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A cardiac-null mutation of Prdm16 causes hypotension in mice with cardiac hypertrophy via increased nitric oxide synthase 1

Ji-One Kang, Tae Woong Ha, Hae-Un Jung, Ji Eun Lim, Bermseok Oh

published 21 Jul 2022

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Deletion of SM22α disrupts the structure and function of caveolae and T-tubules in cardiomyocytes, contributing to heart failure

Jun Wu, Wei Wang, Yaomeng Huang, Haochen Wu, Jiabin Wang, Mei Han

published 18 Jul 2022

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Sex-, age-, and organ-dependent improvement of bile acid hydrophobicity by ursodeoxycholic acid treatment: A study using a mouse model with human-like bile acid composition

Hajime Ueda, Akira Honda, Teruo Miyazaki, Yukio Morishita, Takeshi Hirayama, Junichi Iwamoto, Nobuhiro Nakamoto, Tadashi Ikegami

published 12 Jul 2022

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Mitochondrial dysfunction is associated with lipid metabolism disorder and upregulation of angiotensin-converting enzyme 2

Qian Zhao, Xiaoshan Zhou, Raoul Kuiper, Sophie Curbo, Anna Karlsson

published 29 Jun 2022

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Metabolic changes in vitamin D receptor knockout mice

Sue Lynn Lau, Rebecca A. Stokes, Beverly Ng, Kim Cheng, Roderick Clifton-Bligh, Jenny E. Gunton

published 17 Jun 2022

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Pattern of tamoxifen-induced Tie2 deletion in endothelial cells in mature blood vessels using endo SCL-Cre-ERT transgenic mice

Peter J. Zwiers, Rianne M. Jongman, Timara Kuiper, Jill Moser, Radu V. Stan, Joachim R. Göthert, Matijs van Meurs, Eliane R. Popa, Grietje Molema

published 08 Jun 2022

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Investigating CRISPR/Cas9 gene drive for production of disease-preventing prion gene alleles

Andrew R. Castle, Serene Wohlgemuth, Luis Arce, David Westaway

published 07 Jun 2022

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Resveratrol-nitric oxide donor hybrid effect on priapism in sickle cell and nitric oxide-deficient mouse

Andressa Kely Pinheiro, Dalila Andrade Pereira, Jean Leandro dos Santos, Fabiano Beraldi Calmasini, Eduardo Costa Alexandre, Leonardo Oliveira Reis, Arthur L. Burnett, Fernando Ferreira Costa, Fábio Henrique Silva

published 02 Jun 2022

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15-PGDH regulates hematopoietic and gastrointestinal fitness during aging

Won Jin Ho, Julianne N. P. Smith, Young Soo Park, Matthew Hadiono, Kelsey Christo, Alvin Jogasuria, Yongyou Zhang, Alyssia V. Broncano, Lakshmi Kasturi, Dawn M. Dawson, Stanton L. Gerson, Sanford D. Markowitz, Amar B. Desai

published 19 May 2022

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Endosomal structure and APP biology are not altered in a preclinical mouse cellular model of Down syndrome

Claudia Cannavo, Karen Cleverley, Cheryl Maduro, Paige Mumford, Dale Moulding, Elizabeth M. C. Fisher, Frances K. Wiseman

published 11 May 2022

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Holocarboxylase synthetase knockout is embryonic lethal in mice

Mahrou Sadri, Haichuan Wang, Toshinobu Kuroishi, Yong Li, Janos Zempleni

published 06 Apr 2022

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The voltage-gated Ca²⁺ channel subunit α₂δ-4 regulates locomotor behavior and sensorimotor gating in mice

Annette Klomp, Ryotaro Omichi, Yoichiro Iwasa, Richard J. Smith, Yuriy M. Usachev, Andrew F. Russo, Nandakumar S. Narayanan, Amy Lee

published 30 Mar 2022

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