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Genetically modified animals

Mice lacking Ptprd exhibit deficits in goal-directed behavior and female-specific impairments in sensorimotor gating

Emily V. Ho, Amanda Welch, Summer L. Thompson, James A. Knowles, Stephanie C. Dulawa

published 19 May 2023

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A comparison of machine learning approaches for the quantification of microglial cells in the brain of mice, rats and non-human primates

Danish M. Anwer, Francesco Gubinelli, Yunus A. Kurt, Livija Sarauskyte, Febe Jacobs, Chiara Venuti, Ivette M. Sandoval, Yiyi Yang, Jennifer Stancati, Martina Mazzocchi, Edoardo Brandi, Gerard O’Keeffe, Kathy Steece-Collier, Jia-Yi Li, Tomas Deierborg, Fredric P. Manfredsson, Marcus Davidsson, Andreas Heuer

published 01 May 2023

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Synonymous alterations of cancer-associated Trp53 CpG mutational hotspots cause fatal developmental jaw malocclusions but no tumors in knock-in mice

Richard J. Epstein, Frank P. Y. Lin, Robert A. Brink, James Blackburn

published 13 Apr 2023

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Preclinical trials in Alzheimer’s disease: Sample size and effect size for behavioural and neuropathological outcomes in 5xFAD mice

Mahvish Faisal, Jana Aid, Bekzod Nodirov, Benjamin Lee, Miriam A. Hickey

published 10 Apr 2023

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In vitro spermatogenesis in isolated seminiferous tubules of immature mice

Xuemin Feng, Takafumi Matsumura, Yuki Yamashita, Takuya Sato, Kiyoshi Hashimoto, Hisakazu Odaka, Yoshinori Makino, Yuki Okada, Hiroko Nakamura, Hiroshi Kimura, Teruo Fujii, Takehiko Ogawa

published 06 Apr 2023

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A seeding-based neuronal model of tau aggregation for use in drug discovery

Ines S. Amorim, Sylvie Challal, Laetitia Cistarelli, Thierry Dorval, Laurene Abjean, Manuelle Touzard, Nicolas Arbez, Arnaud François, Fany Panayi, Ross Jeggo, Erika Cecon, Atsuro Oishi, Julie Dam, Ralf Jockers, Patricia Machado

published 04 Apr 2023

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High signal-to-noise imaging of spontaneous and 5 ns electric pulse-evoked Ca²⁺ signals in GCaMP6f-expressing adrenal chromaffin cells isolated from transgenic mice

Ciara Viola, Thomas W. Gould, Nicole Procacci, Normand Leblanc, Josette Zaklit, Gale L. Craviso

published 31 Mar 2023

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Mitotic CDK1 and 4E-BP1 II: A single phosphomimetic mutation in 4E-BP1 induces glucose intolerance in mice

Simon Cao, Michael J. Jurczak, Yoko Shuda, Rui Sun, Masahiro Shuda, Yuan Chang, Patrick S. Moore

published 10 Mar 2023

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Targeting nonsense-mediated RNA decay does not increase progranulin levels in the Grn ^R493X mouse model of frontotemporal dementia

Denise M. Smith, Michael L. Niehoff, Karen Ling, Paymaan Jafar-Nejad, Frank Rigo, Susan A. Farr, Miles F. Wilkinson, Andrew D. Nguyen

published 09 Mar 2023

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Increased number of T cells and exacerbated inflammatory pathophysiology in a human IgG4 knock-in MRL/lpr mouse model

Yoshie Gon, Tsugumitsu Kandou, Tatsuaki Tsuruyama, Takeshi Iwasaki, Koji Kitagori, Kosaku Murakami, Ran Nakashima, Shuji Akizuki, Akio Morinobu, Masaki Hikida, Tsuneyo Mimori, Hajime Yoshifuji

published 10 Feb 2023

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Heterozygous deletion of Gpr55 does not affect a hyperthermia-induced seizure, spontaneous seizures or survival in the Scn1a^+/^- mouse model of Dravet syndrome

Lyndsey L. Anderson, Dilara A. Bahceci, Nicole A. Hawkins, Declan Everett-Morgan, Samuel D. Banister, Jennifer A. Kearney, Jonathon C. Arnold

published 26 Jan 2023

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Direct implantation of hair-follicle-associated pluripotent (HAP) stem cells repairs intracerebral hemorrhage and reduces neuroinflammation in mouse model

Koya Obara, Kyoumi Shirai, Yuko Hamada, Nobuko Arakawa, Ayami Hasegawa, Nanako Takaoka, Ryoichi Aki, Robert M. Hoffman, Yasuyuki Amoh

published 13 Jan 2023

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Lack of the Ig cell adhesion molecule BT-IgSF (IgSF11) induced behavioral changes in the open maze, water maze and resident intruder test

Dirk Montag, Laura Pelz, Fritz G. Rathjen

published 06 Jan 2023

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