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Genetically modified animals

Mitochondrial oxidative stress promotes the accumulation of advanced glycation end products

Firoz Akhter, Sourav Samanta, Alexandre A. Sosunov, Huawei Wu, Ethan Kim Tieu, Shi Fang Yan, Shirley ShiDu Yan

published 23 Jun 2026

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Bone marrow CCR3 dictates eosinophil lineage commitment of CD34⁺ progenitors to orchestrate allergic rhinitis: A composite study

Zhi-qiang Zhang, Meng-yi Wei, Jia-le Bei, Jing-yang Li, Mei-na Dai, Yin-li Jiang, Ya-ting Xiao, Ying Zhang, Xinhua Zhu

published 22 Jun 2026

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Neutrophil extracellular traps in the animal model of adenine-induced chronic kidney disease

Alexandra Gaál Kovalčíková, Gabriela Forraiová, Nelia Korotushak, Veronika Borbélyová, Diana Vavrincová-Yaghi, Peter Vavrinec, Ľudmila Podracká, Peter Celec

published 05 Jun 2026

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Significance of RGS13 expression in lupus B cells

Tomoya Nakajima, Koji Kitagori, Sohei Funakoshi, Mirei Shirakashi, Ryosuke Hiwa, Hideaki Tsuji, Shuji Akizuki, Ran Nakashima, Akio Morinobu, Hajime Yoshifuji

published 08 May 2026

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Poldip2 deficiency attenuates lung disease severity in a mouse model of COVID-19

Ruinan Hu, Alejandra Valdivia, Taylor White, Willy Ju, Maegan L. Brockman, Zhan Zhang, Hongyan Qu, Georgette Gafford, Giji Joseph, Samantha Burton, Leda Bassit, Tysheena P. Charles, Raymond F. Schinazi, Rebecca D. Levit, Cynthia A. Derdeyn, Kathy K. Griendling, Bernard Lassègue, Marina S. Hernandes

published 29 Apr 2026

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ATRX function beyond hippocampal CA1 is required for cognitive deficits in mouse models of intellectual disability

Julia T. Brott, Nathalie G. Bérubé

published 28 Apr 2026

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Ectopic expression of Aspergillus flavus uricase and URAT1 in therapeutic cells promotes intracellular degradation of uric acid in hyperuricemic mice

Yuzhong Feng, Jiazhen Cui, Xuan Huang, Yupeng Li, Haolong Dong, Xianghua Xiong, Gang Liu, Qingyang Wang, Huipeng Chen

published 20 Apr 2026

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Dysregulated lactate metabolism synergizes with ALS genetic risk factors to accelerate motor decline

Shweta Tendulkar, Tong Wu, Amy Strickland, Amber R. Hackett, Yurie Sato-Yamada, Xianrong Mao, Yo Sasaki, Jeffrey Milbrandt, A. Joseph Bloom, Aaron DiAntonio

published 17 Apr 2026

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Primary cilia in osteoblasts and osteocytes are required for skeletal development and mechano-adaptation

Mariana Moraes de Lima Perini, Alyssa F. Fayemi, Julie N. Pugh, Elizabeth M. Scott, Karan Bhula, Austin Chirgwin, Olivia N. White, Nicolas F. Berbari, Jiliang Li

published 02 Apr 2026

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A novel genetic strategy to interrogate an unknown phenotypic modifier: Sdhc KO-Robertsonian mice develop frequent thyroid abnormalities with papillary thyroid carcinoma-like features

Jean-Pierre Bayley, Heggert G. Rebel, Peter Devilee

published 31 Mar 2026

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The METTL3 inhibitor STM2457 suppresses gastric cancer progression by modulating m⁶A RNA modification

Hang Sun, Haozhi Xu, Junying Li, Xiaoman Xie, Junmei Zhang, Hongjie Dong, Huanhuan Xie, Qi Wang, Guihua Zhao, Kun Yin, Jingyu Yang, Jianwei Zhou, Ruili Wu, Chao Xu

published 24 Mar 2026

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Age-associated accumulation of carbamylation-derived products in tissues is independent from the myeloperoxidase pathway in mice

Christine Pietrement, Anaïs Okwieka, Lucile Cadoret, Manon Doué, Philippe Gillery, Stéphane Jaisson

published 16 Mar 2026

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Salt loading as a promising approach to study the dopaminergic phenotype of neurons of the supraoptic nucleus in mice

Alyona E. Bannikova, Tatiana S. Pronina, Dmitry V. Troshev, Vsevolod V. Bogdanov, Anna A. Kolacheva, Ekaterina N. Pavlova, Victor E. Blokhin, Varvara I. Kalashnikova, Michael V. Ugrumov

published 06 Feb 2026

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