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Genetic engineering

Characterization of Behavioral, Neuropathological, Brain Metabolic and Key Molecular Changes in zQ175 Knock-In Mouse Model of Huntington’s Disease

Qi Peng, Bin Wu, Mali Jiang, Jing Jin, Zhipeng Hou, Jennifer Zheng, Jiangyang Zhang, Wenzhen Duan

published 09 Feb 2016

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AKT1^E17K Is Oncogenic in Mouse Lung and Cooperates with Chemical Carcinogens in Inducing Lung Cancer

Donatella Malanga, Stefania Belmonte, Fabiana Colelli, Marzia Scarfò, Carmela De Marco, Duarte Mendes Oliveira, Teresa Mirante, Caterina Camastra, Monica Gagliardi, Antonia Rizzuto, Chiara Mignogna, Orlando Paciello, Serenella Papparella, Henrik Fagman, Giuseppe Viglietto

published 09 Feb 2016

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Establishment of Leptin-Responsive Cell Lines from Adult Mouse Hypothalamus

Hiroshi Iwakura, Katsuko Dote, Mika Bando, Hiroyuki Koyama, Kiminori Hosoda, Kenji Kangawa, Kazuwa Nakao

published 05 Feb 2016

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Overexpression of the NDR1/HIN1-Like Gene NHL6 Modifies Seed Germination in Response to Abscisic Acid and Abiotic Stresses in Arabidopsis

Yan Bao, Wei-Meng Song, Jing Pan, Chun-Mei Jiang, Renu Srivastava, Bei Li, Lu-Ying Zhu, Hong-Yan Su, Xiao-Shu Gao, Hua Liu, Xiang Yu, Lei Yang, Xian-Hao Cheng, Hong-Xia Zhang

published 05 Feb 2016

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Transgenic Expression of the Formin Protein Fhod3 Selectively in the Embryonic Heart: Role of Actin-Binding Activity of Fhod3 and Its Sarcomeric Localization during Myofibrillogenesis

Noriko Fujimoto, Meikun Kan-o, Tomoki Ushijima, Yohko Kage, Ryuji Tominaga, Hideki Sumimoto, Ryu Takeya

published 05 Feb 2016

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A Vector with a Single Promoter for In Vitro Transcription and Mammalian Cell Expression of CRISPR gRNAs

Peter J. Romanienko, Joseph Giacalone, Joanne Ingenito, Yijie Wang, Mayumi Isaka, Thomas Johnson, Yun You, Willie H. Mark

published 05 Feb 2016

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Conditional Deletion of Fgfr1 in the Proximal and Distal Tubule Identifies Distinct Roles in Phosphate and Calcium Transport

Xiaobin Han, Jiancheng Yang, Linqiang Li, Jinsong Huang, Gwendalyn King, L. Darryl Quarles

published 03 Feb 2016

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Activation of Dll4/Notch Signaling and Hypoxia-Inducible Factor-1 Alpha Facilitates Lymphangiogenesis in Lacrimal Glands in Dry Eye

Ji Hwan Min, Chul Hee Lee, Yong Woo Ji, Areum Yeo, Hyemi Noh, Insil Song, Eung Kweon Kim, Hyung Keun Lee

published 01 Feb 2016

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Prader-Willi Critical Region, a Non-Translated, Imprinted Central Regulator of Bone Mass: Possible Role in Skeletal Abnormalities in Prader-Willi Syndrome

Ee-Cheng Khor, Bruce Fanshawe, Yue Qi, Sergei Zolotukhin, Rishikesh N. Kulkarni, Ronaldo F. Enriquez, Louise Purtell, Nicola J. Lee, Natalie K. Wee, Peter I. Croucher, Lesley Campbell, Herbert Herzog, Paul A. Baldock

published 29 Jan 2016

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SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington’s Disease Mice

Raffaella Tulino, Agnesska C. Benjamin, Nelly Jolinon, Donna L. Smith, Eduardo N. Chini, Alisia Carnemolla, Gillian P. Bates

published 27 Jan 2016

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Cardiac Effects of Attenuating Gsα - Dependent Signaling

Marcus R. Streit, Celine S. Weiss, Sören Meyer, Marco M. Ochs, Marco Hagenmueller, Johannes H. Riffel, Sebastian J. Buss, Thomas Heger, Hugo A. Katus, Stefan E. Hardt

published 26 Jan 2016

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A Comprehensive Behavioral Test Battery to Assess Learning and Memory in 129S6/Tg2576 Mice

Andrea Wolf, Björn Bauer, Erin L. Abner, Tal Ashkenazy-Frolinger, Anika M. S. Hartz

published 25 Jan 2016

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HCN1 Channels Enhance Rod System Responsivity in the Retina under Conditions of Light Exposure

Vithiyanjali Sothilingam, Stylianos Michalakis, Marina Garcia Garrido, Martin Biel, Naoyuki Tanimoto, Mathias W. Seeliger

published 25 Jan 2016

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