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Genetic engineering

Changes in the miRNA-mRNA Regulatory Network Precede Motor Symptoms in a Mouse Model of Multiple System Atrophy: Clinical Implications

Simon Schafferer, Rimpi Khurana, Violetta Refolo, Serena Venezia, Edith Sturm, Paolo Piatti, Clara Hechenberger, Hubert Hackl, Roman Kessler, Michaela Willi, Ronald Gstir, Anne Krogsdam, Alexandra Lusser, Werner Poewe, Gregor K. Wenning, Alexander Hüttenhofer, Nadia Stefanova

published 10 Mar 2016

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IL-10 Production Is Critical for Sustaining the Expansion of CD5⁺ B and NKT Cells and Restraining Autoantibody Production in Congenic Lupus-Prone Mice

Yuriy Baglaenko, Kieran P. Manion, Nan-Hua Chang, Eric Gracey, Christina Loh, Joan E. Wither

published 10 Mar 2016

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A Variant of GJD2, Encoding for Connexin 36, Alters the Function of Insulin Producing β-Cells

Valentina Cigliola, Celine Populaire, Ciro L. Pierri, Samuel Deutsch, Jacques-Antoine Haefliger, João Fadista, Valeriya Lyssenko, Leif Groop, Rico Rueedi, Fabrizio Thorel, Pedro Luis Herrera, Paolo Meda

published 09 Mar 2016

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Enhanced Gene Expression Rather than Natural Polymorphism in Coding Sequence of the OsbZIP23 Determines Drought Tolerance and Yield Improvement in Rice Genotypes

Avishek Dey, Milan Kumar Samanta, Srimonta Gayen, Soumitra K. Sen, Mrinal K. Maiti

published 09 Mar 2016

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Hsp72 (HSPA1A) Prevents Human Islet Amyloid Polypeptide Aggregation and Toxicity: A New Approach for Type 2 Diabetes Treatment

Paola C. Rosas, Ganachari M. Nagaraja, Punit Kaur, Alexander Panossian, Georg Wickman, L. Rene Garcia, Fahd A. Al-Khamis, Alexzander A. A. Asea

published 09 Mar 2016

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Traditional Chinese Nootropic Medicine Radix Polygalae and Its Active Constituent Onjisaponin B Reduce β-Amyloid Production and Improve Cognitive Impairments

Xiaohang Li, Jin Cui, Yang Yu, Wei Li, Yujun Hou, Xin Wang, Dapeng Qin, Cun Zhao, Xinsheng Yao, Jian Zhao, Gang Pei

published 08 Mar 2016

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Extracellular Release of CD11b by TLR9 Stimulation in Macrophages

Dongbum Kim, Te Ha Kim, Guang Wu, Byoung Kwon Park, Ji-Hee Ha, Yong-Sung Kim, Keunwook Lee, Younghee Lee, Hyung-Joo Kwon

published 08 Mar 2016

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Tissue-Specific Suppression of Thyroid Hormone Signaling in Various Mouse Models of Aging

W. Edward Visser, Cíntia R. Bombardieri, Chantal Zevenbergen, Sander Barnhoorn, Alexandre Ottaviani, Ingrid van der Pluijm, Renata Brandt, Ellen Kaptein, Ramona van Heerebeek, Hans van Toor, George A. Garinis, Robin P. Peeters, Marco Medici, Willy van Ham, Wilbert P. Vermeij, Monique C. de Waard, Ronald R. de Krijger, Anita Boelen, Joan Kwakkel, John J. Kopchick, Edward O. List, Joost P. M. Melis, Veerle M. Darras, Martijn E. T. Dollé, Gijsbertus T. J. van der Horst, Jan H. J. Hoeijmakers, Theo J. Visser

published 08 Mar 2016

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Identification of Gene Expression Differences between Lymphangiogenic and Non-Lymphangiogenic Non-Small Cell Lung Cancer Cell Lines

Erin Regan, Robert C. Sibley, Bercin Kutluk Cenik, Asitha Silva, Luc Girard, John D. Minna, Michael T. Dellinger

published 07 Mar 2016

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Deletion of the Toll-Like Receptor 5 Gene Per Se Does Not Determine the Gut Microbiome Profile That Induces Metabolic Syndrome: Environment Trumps Genotype

Wei Zhang, Riley Hartmann, Hein Min Tun, Charles O. Elson, Ehsan Khafipour, W. Timothy Garvey

published 07 Mar 2016

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Chronic Psychological Stress Disrupted the Composition of the Murine Colonic Microbiota and Accelerated a Murine Model of Inflammatory Bowel Disease

Yohei Watanabe, Sohei Arase, Noriko Nagaoka, Mitsuhisa Kawai, Satoshi Matsumoto

published 07 Mar 2016

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Conditional Inducible Triple-Transgenic Mouse Model for Rapid Real-Time Detection of HCV NS3/4A Protease Activity

Min Yao, Xin Lu, Yingfeng Lei, Jing Yang, Haiwei Zhao, Qinghua Qiao, Peijun Han, Zhikai Xu, Wen Yin

published 04 Mar 2016

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Contrasting Roles of Islet Resident Immunoregulatory Macrophages and Dendritic Cells in Experimental Autoimmune Type 1 Diabetes

Thomas B. Thornley, Krishna A. Agarwal, Periklis Kyriazis, Lingzhi Ma, Vaja Chipashvili, Jonathan E. Aker, Sarantis Korniotis, Eva Csizmadia, Terry B. Strom, Maria Koulmanda

published 04 Mar 2016

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