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Genetic engineering

Loss of Renal Tubular PGC-1α Exacerbates Diet-Induced Renal Steatosis and Age-Related Urinary Sodium Excretion in Mice

Kristoffer Svensson, Svenia Schnyder, Bettina Cardel, Christoph Handschin

published 27 Jul 2016

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Tau Protein Mediates APP Intracellular Domain (AICD)-Induced Alzheimer’s-Like Pathological Features in Mice

Kaushik Ghosal, Qingyuan Fan, Hana N. Dawson, Sanjay W. Pimplikar

published 26 Jul 2016

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Phenotypes Associated with Knockouts of Eight Dense Granule Gene Loci (GRA2-9) in Virulent Toxoplasma gondii

Leah M. Rommereim, Valeria Bellini, Barbara A. Fox, Graciane Pètre, Camille Rak, Bastien Touquet, Delphine Aldebert, Jean-François Dubremetz, Marie-France Cesbron-Delauw, Corinne Mercier, David J. Bzik

published 26 Jul 2016

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Tubular Overexpression of Angiopoietin-1 Attenuates Renal Fibrosis

Sudhir Singh, Scott R. Manson, Heedoo Lee, Yeawon Kim, Tuoen Liu, Qiusha Guo, Julio J. Geminiani, Paul F. Austin, Ying Maggie Chen

published 25 Jul 2016

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Retinal Neuroprotective Effects of Flibanserin, an FDA-Approved Dual Serotonin Receptor Agonist-Antagonist

Aaron S. Coyner, Renee C. Ryals, Cristy A. Ku, Cody M. Fischer, Rachel C. Patel, Shreya Datta, Paul Yang, Yuquan Wen, René Hen, Mark E. Pennesi

published 22 Jul 2016

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Post-Synthetic Defucosylation of AGP by Aspergillus nidulans α-1,2-Fucosidase Expressed in Arabidopsis Apoplast Induces Compensatory Upregulation of α-1,2-Fucosyltransferases

Gennady V. Pogorelko, Nathan T. Reem, Zachary T. Young, Lauran Chambers, Olga A. Zabotina

published 22 Jul 2016

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miR-9 Acts as an OncomiR in Prostate Cancer through Multiple Pathways That Drive Tumour Progression and Metastasis

S. J. Seashols-Williams, W. Budd, G. C. Clark, Q. Wu, R. Daniel, E. Dragoescu, Z. E. Zehner

published 22 Jul 2016

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Ablation of Prion Protein in Wild Type Human Amyloid Precursor Protein (APP) Transgenic Mice Does Not Alter The Proteolysis of APP, Levels of Amyloid-β or Pathologic Phenotype

Isobel J. Whitehouse, Deborah Brown, Herbert Baybutt, Abigail B. Diack, Katherine A. B. Kellett, Pedro Piccardo, Jean C. Manson, Nigel M. Hooper

published 22 Jul 2016

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A New Mouse Model That Spontaneously Develops Chronic Liver Inflammation and Fibrosis

Nina Fransén-Pettersson, Nadia Duarte, Julia Nilsson, Marie Lundholm, Sofia Mayans, Åsa Larefalk, Tine D. Hannibal, Lisbeth Hansen, Anja Schmidt-Christensen, Fredrik Ivars, Susanna Cardell, Richard Palmqvist, Björn Rozell, Dan Holmberg

published 21 Jul 2016

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Inhibition of the Unfolded Protein Response Mechanism Prevents Cardiac Fibrosis

Jody Groenendyk, Dukgyu Lee, Joanna Jung, Jason R. B. Dyck, Gary D. Lopaschuk, Luis B. Agellon, Marek Michalak

published 21 Jul 2016

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Suppression of Reactive Oxygen Species Accumulation in Chloroplasts Prevents Leaf Damage but Not Growth Arrest in Salt-Stressed Tobacco Plants

Anabella F. Lodeyro, Mariana Giró, Hugo O. Poli, Gabriel Bettucci, Adriana Cortadi, Alejandro M. Ferri, Néstor Carrillo

published 21 Jul 2016

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Loss of Fertility in the Absence of Progesterone Receptor Expression in Kisspeptin Neurons of Female Mice

Arnon Gal, Po-Ching Lin, Joseph A. Cacioppo, Patrick R. Hannon, Megan M. Mahoney, Andrew Wolfe, Rodrigo Fernandez-Valdivia, John P. Lydon, Carol F. Elias, CheMyong Ko

published 21 Jul 2016

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Critical Role of Kupffer Cell CD89 Expression in Experimental IgA Nephropathy

Lijun Xu, Bingyu Li, Mengwen Huang, Kun Xie, Dong Li, You Li, Hua Gu, Jianmin Fang

published 20 Jul 2016

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