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Genetic engineering

Disruption of adaptive immunity does not attenuate disease in the Ndufs4(-/-) model of Leigh syndrome

Allison R. Hanaford, Asheema Khanna, Vivian Truong, Katerina James, Ryan Liao, Yihan Chen, Michael Mulholland, Ernst-Bernhard Kayser, Kino Watanabe, Erin Shien Hsieh, Philip G. Morgan, Surojit Sarkar, Vandana Kalia, Simon C. Johnson

published 10 Jun 2025

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Generation and characterization of BAC transgenic mouse lines expressing a fluorescent protein in trigeminal and dorsal root ganglion neurons

Piu Banerjee, Takuya Sato, Takuji Iwasato

published 06 Jun 2025

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Variants in Lrrk2 and Snca deficiency do not alter the course of primary encephalitis due to neurotropic reovirus T3D in newborn mice

Michaela O. Lunn, Christopher Rousso, Julianna J. Tomlinson, Earl G. Brown, Michael G. Schlossmacher

published 05 Jun 2025

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Cnot4 heterozygosity attenuates high fat diet-induced obesity in mice and impairs PPARγ-mediated adipocyte differentiation

Tomokazu Yamaguchi, Midori Hoshizaki, Yumiko Imai, Tadashi Yamamoto, Keiji Kuba

published 27 May 2025

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Inhibition of VE-PTP rejuvenates Schlemm’s canal in aged mice and acts via Tie2

Sarthak Mishra, Ute Ipe, Astrid F. Nottebaum, Kevin G. Peters, Dietmar Vestweber

published 16 May 2025

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Success and limitations in adaptation of Fast-TrACC tissue culture-independent transformation in coffee, cotton, and tree tobacco

Boaz Negin, Laura Daniela Martin-Lesmes, Georg Jander

published 15 May 2025

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Protective function of the voltage-gated potassium channel Kv11.3 in a mouse model of cardiac ischemia/reperfusion injury

Hayato Sasaki, Kazuki Otake, Kazuki Takeda, Karin Tesaki, Eiki Takahashi, Jumpei Yasuda, Shizukaze Matsuda, Ayumu Kawasaki, Masaki Watanabe, Kosuke Otani, Muneyoshi Okada, Masakazu Sekijima, Hideyuki Yamawaki, Nobuya Sasaki

published 07 May 2025

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AAV delivery of GBA1 suppresses α-synuclein accumulation in Parkinson’s disease models and restores functions in Gaucher’s disease models

Takuro Okai, Sho Sato, Mugdha Deshpande, Shin-ichi Matsumoto, Miyu Nakayama, Syunsuke Yamamoto, Bettina Strack-Logue, Takeshi Hioki, Maiko Tanaka, Gabriele Proetzel

published 07 May 2025

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Human cytomegalovirus-IE2 suppresses antigen presentation of macrophage through the IL10/STAT3 signalling pathway in transgenic mouse

Xianjuan Zhang, Qing Wang, Shuo Han, Guanghui Song, Bin Wang, Yunyang Wang

published 05 May 2025

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Adipocyte-specific deletion of Dbc1 does not recapitulate healthy obesity phenotype but suggests regulation of inflammation signaling

Leonardo Santos, Rafael Sebastián Fort, Geraldine Schlapp, Karina Cal, Valentina Perez-Torrado, Maria Noel Meikle, Ana Paula Mulet, Camila Espasandín, Camila Chiesa, José R. Sotelo-Silveira, Jose M. Verdes, Paola Contreras, Aldo J. Calliari, Martina Crispo, Jose L. Badano, Carlos Escande

published 02 May 2025

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Polyhydroxyalkanoate production in Priestia megaterium strains from glycerol feedstock

Andrew J. Cal, Victor J. Chan, Winston K. Luo, Charles C. Lee

published 30 Apr 2025

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A mix-and-match reverse genetics system for evaluating genetic determinants of orthobunyavirus neurological disease

Heini M. Miettinen, Matthew J. Abbott, Alyssa B. Evans

published 28 Apr 2025

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Molecular cloning and functional verification of chalcone synthase genes from cassava (Manihot esculenta Crantz) in defense against Tetranychus cinnabarinus infestation

Yanni Yang, Kaiwen Zheng, Limei Gao, Yakang Hu, Cuixia Liu, Fei Li, Ming Liu

published 24 Apr 2025

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