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Genetic engineering

Disrupting ribulose-5-phosphate metabolic flux enhances riboflavin production in Escherichia coli BL21(DE3)

Junhui Ying, Jin Lu, Qiming Liu, Yingjie Pan, Xianfeng Bao, Junjun Yin, Bing Fu

published 14 Nov 2025

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UDP-glucuronic acid availability underlies sex difference in renal expression of nonsulfated Human Natural Killer-1 (HNK-1) glycans

Tomoko Onishi, Hajime Okayama, Hitomi Kitano, Katsuaki Higashi, Naoki Nakagawa, Motohiro Nonaka, Shogo Oka, Jyoji Morise

published 13 Nov 2025

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Behavioral analyses of a forebrain glutamatergic neuron specific Ywhae conditional knockout mouse model

Meaghan Navarrete-Mathews, Gloria S. Lee, Angel Walerio, Dylan Horne, Yuying Wu, Yi Zhou

published 11 Nov 2025

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Deletion of the scavenger receptor Scarb1 in osteoblast progenitors and myeloid cells does not affect bone mass

Michela Palmieri, Teenamol E. Joseph, Horacio Gomez-Acevedo, Ha-Neui Kim, Stavros C. Manolagas, Charles A. O’Brien, Elena Ambrogini

published 31 Oct 2025

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One IV HEDGES DNA vector administration encoding hGLA or hGH produces durable hGLA and hGH serum lvels in immunocompetent mice

Alice Ye, Marissa Mack, Sarah Ursu, Stephen Chmura, Robert Steiner, Tim Heath, Chakkrapong Handumrongkul, Robert Debs

published 31 Oct 2025

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Eliosin-an alternative product from the HmPKD1 locus is a component of endoplasmic reticulum mitochondria membrane contact sites

Almira Kurbegovic, Virginie Lazar, Wei-Min Xu, Maya Seshan, John S. Underwood, Radmila Micanovic, Jeremy M. Pomerantz, Rajneesh Srivastava, Sarath Janga, Emma H. Doud, Sherry Clendenon, Marie Trudel, Angela Wandinger-Ness, Robert L. Bacallao

published 30 Oct 2025

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Volumetric MRI of dorsal root ganglia as a biomarker for disease progression and response to AAV treatment in a mouse model of Fabry disease

Fuqiang Zhao, Shipeng Yuan, Charalambos Kaittanis, Mugdha Deshpande, Abirami Kugadas, Katayoun Derakhchan, Wanida Ruangsiriluk, Rizwana Islam, Natalia Boukharov, Paul McQuade, Johannes Tauscher, Christopher T. Winkelmann, Talakad G. Lohith

published 24 Oct 2025

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GMO approvals under pressure: How climate shocks shape policy across nations

Xiangwen Kong

published 22 Oct 2025

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Functional connectivity patterns of the Giant Toad Rhinella horribilis in anthropogenically modified landscapes

Gerardo J. Soria-Ortiz, Leticia M. Ochoa-Ochoa, Juan P. Jaramillo-Correa, Íñigo Martínez-Solano, Ella Vázquez-Domínguez

published 15 Oct 2025

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Caveolin-1 knockout improves CFA-induced inflammatory pain in adult mice through modulating the cGAS STING pathway and autophagy

Huan Chang, Cancan Cheng, Ning Zheng, Haiyan Zhu, Hui Yang, Xiaocheng Zhu, Fan Zhang

published 09 Oct 2025

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Post-pleistocene colonisation rather than the contemporary environment has most influenced the current population structure of Scottish Atlantic salmon (Salmo salar)

Finn Cowell, Oscar E. Gaggiotti, Eef Cauwelier

published 01 Oct 2025

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Gene electrotransfer with flow-through microchannel and lower alternating voltage generated induced pluripotent cells from human lymphoblastoid cell lines

Miho Ishii-Teshima, Koki Maeda, Kazuki Hanauchi, Emika Asechi, Defan Setyawan, Takeshi Niki, Kenji Nakashima, Hirofumi Kurita, Rika Numano, Takayuki Shibata

published 26 Sep 2025

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Liver-specific glucagon dysfunction promotes PP-cell hyperplasia and formation of glucagon and PP double-positive cells

Yuko Nakagawa, Takuro Horii, Ayako Fukunaka, Takashi Sato, Zhehao Zhang, Masaki Kobayashi, Tadahiro Kitamura, Yoshitaka Hayashi, Takashi Nishimura, Izuho Hatada, Yoshio Fujitani

published 23 Sep 2025

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