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Genetic engineering

Optimizing sgRNA length to improve target specificity and efficiency for the GGTA1 gene using the CRISPR/Cas9 gene editing system

Anders W. Matson, Nora Hosny, Zachary A. Swanson, Bernhard J. Hering, Christopher Burlak

published 10 Dec 2019

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Replacing murine insulin 1 with human insulin protects NOD mice from diabetes

Colleen M. Elso, Nicholas A. Scott, Lina Mariana, Emma I. Masterman, Andrew P. R. Sutherland, Helen E. Thomas, Stuart I. Mannering

published 10 Dec 2019

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Isolation and characterization of the EgWRI1 promoter from oil palm (Elaeis guineensis Jacq.) and its response to environmental stress and ethylene

Qing Zhang, Ruhao Sun, Yusheng Zheng, Yijun Yuan, Dongdong Li

published 04 Dec 2019

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Expressional artifact caused by a co-injection marker rol-6 in C. elegans

HoYong Jin, Scott W. Emmons, Byunghyuk Kim

published 04 Dec 2019

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Public attitudes toward genetic modification in dairy cattle

Caroline Ritter, Adam Shriver, Emilie McConnachie, Jesse Robbins, Marina A. G. von Keyserlingk, Daniel M. Weary

published 02 Dec 2019

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Ex vivo perfusion-based engraftment of genetically engineered cell sensors into transplantable organs

Ling-Yee Chin, Cailah Carroll, Siavash Raigani, Danielle M. Detelich, Shannon N. Tessier, Gregory R. Wojtkiewicz, Stephen P. Schmidt, Ralph Weissleder, Heidi Yeh, Korkut Uygun, Biju Parekkadan

published 02 Dec 2019

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Improved chemotherapy modeling with RAG-based immune deficient mice

Mark Wunderlich, Nicole Manning, Christina Sexton, Anthony Sabulski, Luke Byerly, Eric O’Brien, John P. Perentesis, Benjamin Mizukawa, James C. Mulloy

published 20 Nov 2019

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Beyond detoxification: Pleiotropic functions of multiple glutathione S-transferase isoforms protect mice against a toxic electrophile

Kelsey A. Behrens, Leigh A. Jania, John N. Snouwaert, MyTrang Nguyen, Sheryl S. Moy, Andrey P. Tikunov, Jeffrey M. Macdonald, Beverly H. Koller

published 20 Nov 2019

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Overexpression of Saussurea involucrata dehydrin gene SiDHN promotes cold and drought tolerance in transgenic tomato plants

Xinyong Guo, Li Zhang, Xiaozhen Wang, Minhuan Zhang, Yuxin Xi, Aiying Wang, Jianbo Zhu

published 18 Nov 2019

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Non-invasive in vivo imaging of UCP1 expression in live mice via near-infrared fluorescent protein iRFP720

Aya Fukuda, Shiho Honda, Norie Fujioka, Yuya Sekiguchi, Seiya Mizuno, Yoshihiro Miwa, Fumihiro Sugiyama, Yohei Hayashi, Ken Nishimura, Koji Hisatake

published 15 Nov 2019

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Autophagy deficiency exacerbates colitis through excessive oxidative stress and MAPK signaling pathway activation

Minori Kubota, Kazuki Kakimoto, Takatoshi Nakagawa, Eiko Koubayashi, Kei Nakazawa, Hideki Tawa, Yuki Hirata, Toshihiko Okada, Ken Kawakami, Akira Asai, Shuhei Hosomi, Toshihisa Takeuchi, Shinya Fukunishi, Takuya Inoue, Michio Asahi, Kazuhide Higuchi

published 08 Nov 2019

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Signaling impacts of GMO labeling on fruit and vegetable demand

D. Adeline Yeh, Miguel I. Gómez, Harry M. Kaiser

published 30 Oct 2019

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APOL1-G0 protects podocytes in a mouse model of HIV-associated nephropathy

Leslie A. Bruggeman, Zhenzhen Wu, Liping Luo, Sethu Madhavan, Paul E. Drawz, David B. Thomas, Laura Barisoni, John F. O'Toole, John R. Sedor

published 29 Oct 2019

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