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Genetic engineering

Renal and hepatic function is preserved following inducible knockout of kynurenine pathway enzymes KMO or QPRT in adult mice

Benjamin S. Summers, Luke Milham, [ ... ], Bruce J. Brew

The METTL3 inhibitor STM2457 suppresses gastric cancer progression by modulating m⁶A RNA modification

Hang Sun, Haozhi Xu, [ ... ], Chao Xu

UTX/Top2β axis mediated spinal cord microvascular endothelial cells senescence exacerbates spinal cord injury

Dongliang Liu, Yudong Liu, Tianding Wu, Jianzhong Hu

ACE1 does not influence cerebral Aβ degradation or amyloid plaque accumulation in 5XFAD mice

Sohee Jeon, Alia O. Alia, [ ... ], Leah K. Cuddy

Transient vascular occlusions in a zebrafish model of mycobacterial brain infection

Megan I. Hayes, Sumedha Ravishankar, [ ... ], Cressida A. Madigan

Disrupting ribulose-5-phosphate metabolic flux enhances riboflavin production in Escherichia coli BL21(DE3)

Junhui Ying, Jin Lu, [ ... ], Bing Fu

Liver-specific glucagon dysfunction promotes PP-cell hyperplasia and formation of glucagon and PP double-positive cells

Yuko Nakagawa, Takuro Horii, [ ... ], Yoshio Fujitani

One IV HEDGES DNA vector administration encoding hGLA or hGH produces durable hGLA and hGH serum lvels in immunocompetent mice

Alice Ye, Marissa Mack, [ ... ], Robert Debs

Analysis of disease resistance of ZmERS4 -overexpressing rice

Wanyuan Huang, Jun Ning, [ ... ], Ting Ding

Development of a floxed Gabbr2 gene allows for widespread conditional disruption of GABBR2 and recapitulates the phenotype of germline Gabbr2 knockout mice

Julie Rose Hens, Stacey Brown, [ ... ], John J. Wysolmerski

UDP-glucuronic acid availability underlies sex difference in renal expression of nonsulfated Human Natural Killer-1 (HNK-1) glycans

Tomoko Onishi, Hajime Okayama, [ ... ], Jyoji Morise

Dysregulated lactate metabolism synergizes with ALS genetic risk factors to accelerate motor decline

Shweta Tendulkar, Tong Wu, [ ... ], Aaron DiAntonio

Generation and characterization of a mouse model of conditional Chd4 knockout in the endometrial epithelium

Shannon K. Harkins, Hilary J. Skalski, [ ... ], Ronald L. Chandler

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