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Genetic engineering

Suppression of RNA-dependent RNA polymerase 6 in tomatoes allows potato spindle tuber viroid to invade basal part but not apical part including pluripotent stem cells of shoot apical meristem

Takashi Naoi, Syoya Kitabayashi, Atsushi Kasai, Kohei Sugawara, Charith Raj Adkar-Purushothama, Mineo Senda, Tatsuji Hataya, Teruo Sano

published 27 Jul 2020

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Development of a brain-permeable peptide nanofiber that prevents aggregation of Alzheimer pathogenic proteins

Naoki Tanaka, Michiaki Okuda, Tatsutoshi Nishigaki, Nobuhiko Tsuchiya, Yukako Kobayashi, Takuya Uemura, Sayaka Kumo, Hachiro Sugimoto, Seiji Miyata, Tomonori Waku

published 24 Jul 2020

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Keratinocyte-specific deletion of SHARPIN induces atopic dermatitis-like inflammation in mice

John P. Sundberg, C. Herbert Pratt, Leslie P. Goodwin, Kathleen A. Silva, Victoria E. Kennedy, Christopher S. Potter, Anisa Dunham, Beth A. Sundberg, Harm HogenEsch

published 20 Jul 2020

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Complementary epitopes and favorable developability of monoclonal anti-LAMP1 antibodies generated using two transgenic animal platforms

Beatrice Cameron, Tarik Dabdoubi, Laurence Berthou-Soulié, Marie Gagnaire, Isabelle Arnould, Anne Severac, Fabienne Soubrier, Jacqueline Morales, Philip A. Leighton, William Harriman, Kathryn Ching, Yasmina Abdiche, Katarina Radošević, Thomas Bouquin

published 16 Jul 2020

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Correlation of pyroglutamate amyloid β and ptau Ser202/Thr205 levels in Alzheimer’s disease and related murine models

Joerg Neddens, Magdalena Daurer, Stefanie Flunkert, Kerstin Beutl, Tina Loeffler, Lauren Walker, Johannes Attems, Birgit Hutter-Paier

published 09 Jul 2020

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The heterologous expression of a soybean (Glycine max) xyloglucan endotransglycosylase/hydrolase (XTH) in cotton (Gossypium hirsutum) suppresses parasitism by the root knot nematode Meloidogyne incognita

Prakash M. Niraula, Katherine S. Lawrence, Vincent P. Klink

published 06 Jul 2020

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PD-L1 upregulation by IFN-α/γ-mediated Stat1 suppresses anti-HBV T cell response

LanLan Liu, Junwei Hou, Yuxiu Xu, Lijuan Qin, Weiwei Liu, Han Zhang, Yang Li, Mi Chen, Mengmeng Deng, Bao Zhao, Jun Hu, Huaguo Zheng, Changfei Li, Songdong Meng

published 06 Jul 2020

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Sarm1 knockout protects against early but not late axonal degeneration in experimental allergic encephalomyelitis

Kenneth Viar, Daniel Njoku, Julie Secor McVoy, Unsong Oh

published 25 Jun 2020

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Stacking triple genes increased proanthocyanidins level in Arabidopsis thaliana

Jiebing Wei, Junfeng Yang, Wenbo Jiang, Yongzhen Pang

published 25 Jun 2020

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Determination of metformin bio-distribution by LC-MS/MS in mice treated with a clinically relevant paradigm

Kiran Chaudhari, Jianmei Wang, Yong Xu, Ali Winters, Linshu Wang, Xiaowei Dong, Eric Y. Cheng, Ran Liu, Shao-Hua Yang

published 11 Jun 2020

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An embryo lethal transgenic line manifests global expression changes and elevated protein/oil ratios in heterozygous soybean plants

Sarah I. Jones, Matt R. Hunt, Lila O. Vodkin

published 09 Jun 2020

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Monitoring the autophagy-endolysosomal system using monomeric Keima-fused MAP1LC3B

Hideki Hayashi, Ting Wang, Masayuki Tanaka, Sanae Ogiwara, Chisa Okada, Masatoshi Ito, Nahoko Fukunishi, Yumi Iida, Ayaka Nakamura, Ayumi Sasaki, Shunji Amano, Kazuhiro Yoshida, Asako Otomo, Masato Ohtsuka, Shinji Hadano

published 08 Jun 2020

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Growth differentiation factor-15 slows the growth of murine prostate cancer by stimulating tumor immunity

Yasmin Husaini, Vicky Wang-Wei Tsai, Rakesh Manandhar, Hong Ping Zhang, Ka Ki Michelle Lee-Ng, Hélène Lebhar, Christopher P. Marquis, David A. Brown, Samuel N. Breit

published 05 Jun 2020

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