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Genetic engineering

Molecular remodeling of the myocardium in mice with melanocortin-4 receptor deletion before cardiac function impairment

Xiaomei Wang, Yuanmin Qi, Ziming Zhu, Caiqin Wang, Zhimin Zhang, Haocheng Jia, Linhui Xia, Kai Meng, Jinxiang Yuan

published 30 Jan 2026

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PFKFB3 exacerbates myocardial injury by accelerating CXCR4^hi neutrophil mobilization after acute myocardial infarction

Yingjia Xu, Min Xiao, Qin Zhu, Wutao Wang, Danrui Wang, Dadong Liu, Zongying Yu

published 29 Jan 2026

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HEDGES co-prevents both SARS-CoV-2 and pandemic influenza infection in mice by rapid, durable co-production of twelve different anti-pandemic monoclonal antibodies

Marissa Mack, Alice Ye, Sarah Ursu, Ryan Ice, Liliana Soroceanu, Stan Shoor, Sean McAllister, Tim Heath, Chakkrapong Handumrongkul, Robert Debs

published 23 Jan 2026

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Monitoring of Cd and GSH contents and Bn-OASTL expression in transgenic tobacco seedlings in response to Cd stress

Xiaolan He, Jianwei Wang, Wenxu Li, Xinhong Chen

published 22 Jan 2026

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Effects of combination therapy of a CDK4/6 and MEK inhibitor in diffuse midline glioma preclinical models

Yusuke Tomita, Gabrielle Link, Yi Ge, Emma R. H. Gold, Anna Racanelli, Herminio Joey Cardona, Megan Romero, Samantha Gadd, Jun Watanabe, Eita Uchida, Rintaro Hashizume, Nozomu Takata, Gonzalo Pinero, Dolores Hambardzumyan, Ivan Spasojevic, Guo Hu, Tammy Hennika, Daniel J. Brat, Adam L. Green, Oren J. Becher

published 22 Dec 2025

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Generation and characterization of a mouse model of conditional Chd4 knockout in the endometrial epithelium

Shannon K. Harkins, Hilary J. Skalski, Abigail Z. Bennett, Laura A. Pavliscak, Nakati C. Sany, Amelia R. Arendt, Lauren Wood, Genna E. Moldovan, Ronald L. Chandler

published 19 Dec 2025

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Development of a floxed Gabbr2 gene allows for widespread conditional disruption of GABBR2 and recapitulates the phenotype of germline Gabbr2 knockout mice

Julie Rose Hens, Stacey Brown, Pawel Licznerski, Jacqueline Suarez, Elizabeth Jonas, John J. Wysolmerski

published 15 Dec 2025

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UTX/Top2β axis mediated spinal cord microvascular endothelial cells senescence exacerbates spinal cord injury

Dongliang Liu, Yudong Liu, Tianding Wu, Jianzhong Hu

published 12 Dec 2025

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Conditional deletion of Tmem63b does not impact mouse voiding behavior

Marianela G. Dalghi, Wily G. Ruiz, Dennis R. Clayton, Tanmay Parakala-Jain, Marcelo D. Carattino, Yun Stone Shi, Gerard Apodaca

published 05 Dec 2025

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Renal and hepatic function is preserved following inducible knockout of kynurenine pathway enzymes KMO or QPRT in adult mice

Benjamin S. Summers, Luke Milham, Sonia Bustamante, Krishan Gondal, Peggy Rentsch, Gayathri Sundaram, Michael D. Lovelace, Bryce Vissel, Bruce J. Brew

published 04 Dec 2025

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Differential contribution of α2δ auxiliary subunits of voltage-gated calcium channels in mouse models of pain and itch

Joao M. Braz, Madison Jewell, Karnika Bhardwaj, Sian Rodriguez-Rosado, Veronica Craik, Allan I. Basbaum

published 02 Dec 2025

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Dysbiosis of gut microbiota in C57BL/6-Lep^em1hwl/Korl mice during microplastics-caused hepatic metabolism disruption

Yu Sang Choi, Yu Jeong Roh, Ji Eun Kim, Hee Jin Song, Ayun Seol, Su Jeong Lim, Su Ha Wang, Ji Eun Sung, Ye Eun Ryu, Ye Ryeong Kim, Hyun Su Park, Hong Joo Son, Yu Jin Kim, Eun Sang Jung, Sunho Park, Dae Youn Hwang

published 20 Nov 2025

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Development of Ac- and Ds-tagged starter lines for large-scale transposon-mutagenesis in tomato

Alka Kumari, Rachana Ponukumatla, Arun Kumar Pandey, Yellamaraju Sreelakshmi, Rameshwar Sharma

published 19 Nov 2025

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