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Genetic engineering

Hepatocellular Brg1 promotes CCl4-induced liver inflammation, ECM accumulation and fibrosis in mice

Baocai Wang, Benedikt Kaufmann, Carolin Mogler, Suyang Zhong, Yuhan Yin, Zhangjun Cheng, Roland M. Schmid, Helmut Friess, Norbert Hüser, Guido von Figura, Daniel Hartmann

published 30 Nov 2023

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Bacillus subtilis engineered for topical delivery of an antifungal agent

Veronica A. Montgomery, Ethan Cain, Mark P. Styczynski, Mark R. Prausnitz

published 30 Nov 2023

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Two mouse models of Alzheimer’s disease accumulate amyloid at different rates and have distinct Aβ oligomer profiles unaltered by ablation of cellular prion protein

Silvia A. Purro, Michael Farmer, Elizabeth Noble, Claire J. Sarell, Megan Powell, Daniel Yip, Lauren Giggins, Leila Zakka, David X. Thomas, Mark Farrow, Andrew J. Nicoll, Dominic Walsh, John Collinge

published 17 Nov 2023

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Female sex protects against renal edema, but not lung edema, in mice with partial deletion of the endothelial barrier regulator Tie2 compared to male sex

Anoek L. I. van Leeuwen, Elise Beijer, Roselique Ibelings, Nicole A. M. Dekker, Marjolein R. A. van der Steen, Joris J. T. H. Roelofs, Matijs van Meurs, Grietje Molema, Charissa E. van den Brom

published 16 Nov 2023

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Development of a sensitive real-time quaking-induced conversion (RT-QuIC) assay for application in prion-infected blood

Charlotte M. Thomas, M. Khalid F. Salamat, Christopher de Wolf, Sandra McCutcheon, A. Richard Alejo Blanco, Jean C. Manson, Nora Hunter, E. Fiona Houston

published 02 Nov 2023

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Exercise performance is not improved in mice with skeletal muscle deletion of natriuretic peptide clearance receptor

Brigitte Jia, Alexander Hasse, Fubiao Shi, Sheila Collins

published 02 Nov 2023

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A simple and efficient protocol for generating transgenic hairy roots using Agrobacterium rhizogenes

Shaun Ferguson, Nikolaj B. Abel, Dugald Reid, Lene H. Madsen, Thi-Bich Luu, Kasper R. Andersen, Jens Stougaard, Simona Radutoiu

published 01 Nov 2023

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U-Net based vessel segmentation for murine brains with small micro-magnetic resonance imaging reference datasets

Christoph Praschl, Lydia M. Zopf, Emma Kiemeyer, Ines Langthallner, Daniel Ritzberger, Adrian Slowak, Martin Weigl, Valentin Blüml, Nebojša Nešić, Miloš Stojmenović, Kathrin M. Kniewallner, Ludwig Aigner, Stephan Winkler, Andreas Walter

published 12 Oct 2023

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Type 1 diabetes contributes to combined pulmonary fibrosis and emphysema in male alpha 1 antitrypsin deficient mice

Sangmi S. Park, Michelle Mai, Magdalena Ploszaj, Huchong Cai, Lucas McGarvey, Christian Mueller, Itsaso Garcia-Arcos, Patrick Geraghty

published 11 Oct 2023

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Hydroxyurea does not reverse functional alterations of the nitric oxide-cGMP pathway associated with priapism phenotype in corpus cavernosum from sickle cell mouse

Dalila Andrade Pereira, Danillo Andrade Pereira, Pamela da Silva Pereira, Tammyris Helena Rebecchi Silveira, Fabiano Beraldi Calmasini, Leonardo Oliveira Reis, Fernando Ferreira Costa, Fábio Henrique Silva

published 09 Oct 2023

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Rice GA3ox1 modulates pollen starch granule accumulation and pollen wall development

Kun-Ting Hsieh, Chi-Chih Wu, Shih-Jie Lee, Yu-Heng Chen, Shiau-Yu Shiue, Yi-Chun Liao, Su-Hui Liu, I.-Wen Wang, Ching-Shan Tseng, Wen-Hsiung Li, Chang-Sheng Wang, Liang-Jwu Chen

published 09 Oct 2023

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Long term survival and abnormal liver fat accumulation in mice with specific thymidine kinase 2 deficiency in liver tissue

Qian Zhao, Xiaoshan Zhou, Jingyi Yan, Raoul Kuiper, Sophie Curbo, Anna Karlsson

published 05 Oct 2023

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Transcriptome analysis of renal ischemia/reperfusion (I/R) injury in BAFF and BAFF-R deficient mice

Tamara Möckel, Sebastian Boegel, Andreas Schwarting

published 26 Sep 2023

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