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Gene disruption

Disrupting ribulose-5-phosphate metabolic flux enhances riboflavin production in Escherichia coli BL21(DE3)

Junhui Ying, Jin Lu, Qiming Liu, Yingjie Pan, Xianfeng Bao, Junjun Yin, Bing Fu

published 14 Nov 2025

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The putative forkhead transcription factor FhpA is necessary for development, aflatoxin production, and stress response in Aspergillus flavus

Jessica M. Lohmar, Stephanie R. Gross, Carol H. Carter-Wientjes, Brian M. Mack, Qijian Wei, Matthew D. Lebar, Jeffrey W. Cary

published 03 Mar 2025

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Saturated Transposon Analysis in Yeast as a one-step method to quantify the fitness effects of gene disruptions on a genome-wide scale

Enzo Kingma, Floor Dolsma, Leila Iñigo de la Cruz, Liedewij Laan

published 06 Feb 2025

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Evidence for gene essentiality in Leishmania using CRISPR

Wen-Wei Zhang, Greg Matlashewski

published 30 Dec 2024

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HIF3A gene disruption causes abnormal alveoli structure and early neonatal death

Tomoki Kawahata, Kitaru Tanaka, Kyohei Oyama, Jun Ueda, Kensaku Okamoto, Yuichi Makino

published 08 May 2024

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Disruption of T-box transcription factor eomesa results in abnormal development of median fins in Oujiang color common carp Cyprinus carpio

Shiying Song, Bobo Du, Yu-Wen Chung-Davidson, Wenyao Cui, Yaru Li, Honglin Chen, Rong Huang, Weiming Li, Fei Li, Chenghui Wang, Jianfeng Ren

published 02 Mar 2023

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A large-scale genetic screen identifies genes essential for motility in Agrobacterium fabrum

Diana G. Calvopina-Chavez, Robyn E. Howarth, Audrey K. Memmott, Oscar H. Pech Gonzalez, Caleb B. Hafen, Kyson T. Jensen, Alex B. Benedict, Jessica D. Altman, Brittany S. Burnside, Justin S. Childs, Samuel W. Dallon, Alexa C. DeMarco, Kirsten C. Flindt, Sarah A. Grover, Elizabeth Heninger, Christina S. Iverson, Abigail K. Johnson, Jack B. Lopez, McKay A. Meinzer, Brook A. Moulder, Rebecca I. Moulton, Hyrum S. Russell, Tiana M. Scott, Yuka Shiobara, Mason D. Taylor, Kathryn E. Tippets, Kayla M. Vainerere, Isabella C. Von Wallwitz, Madison Wagley, Megumi S. Wiley, Naomi J. Young, Joel S. Griffitts

published 04 Jan 2023

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Cysteinyl leukotriene receptor 1 is dispensable for osteoclast differentiation and bone resorption

Hirofumi Fujita, Aoi Ando, Yohei Mizusawa, Mitsuaki Ono, Takako Hattori, Munenori Habuta, Toshitaka Oohashi, Satoshi Kubota, Hideyo Ohuchi

published 17 Nov 2022

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Functional human genes typically exhibit epigenetic conservation

Daniel Rud, Paul Marjoram, Kimberly Siegmund, Darryl Shibata

published 14 Sep 2021

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Pulsed-electromagnetic-field induced osteoblast differentiation requires activation of genes downstream of adenosine receptors A2A and A3

Niladri S. Kar, Daniel Ferguson, Nianli Zhang, Erik I. Waldorff, James T. Ryaby, Joseph A. DiDonato

published 25 Feb 2021

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Chlamydomonas reinhardtii tubulin-gene disruptants for efficient isolation of strains bearing tubulin mutations

Takako Kato-Minoura, Yutaro Ogiwara, Takashi Yamano, Hideya Fukuzawa, Ritsu Kamiya

published 23 Nov 2020

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Burden of rare deleterious variants in WNT signaling genes among 511 myelomeningocele patients

Luke Hebert, Paul Hillman, Craig Baker, Michael Brown, Allison Ashley-Koch, James E. Hixson, Alanna C. Morrison, Hope Northrup, Kit Sing Au

published 24 Sep 2020

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Repeated sleep disruption in mice leads to persistent shifts in the fecal microbiome and metabolome

Samuel J. Bowers, Fernando Vargas, Antonio González, Shannon He, Peng Jiang, Pieter C. Dorrestein, Rob Knight, Kenneth P. Wright Jr, Christopher A. Lowry, Monika Fleshner, Martha H. Vitaterna, Fred W. Turek

published 20 Feb 2020

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