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Enzyme metabolism

Investigating tryptophan metabolism in colorectal cancer using Single-cell RNA sequencing based on machine learning techniques

Chen Zepeng, Wang Xingchen, Xiao Changfang, Cao Yongqing

published 06 Jul 2026

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Biochemical characterizations of leaves and fruits in Crataegus monogyna Jacq., C. pontica K.Koch, C. microphylla K.Koch, and C. pentagyna Waldst. & Kit. ex Willd

Sama Koliaei, Javad Erfani-Moghadam, Mehdi Saidi, Ali Khadivi, Yazgan Tunç

published 06 Jul 2026

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Pharmacokinetic interactions between three SGLT2 inhibitors and telmisartan: A focus on empagliflozin, ertugliflozin, and henagliflozin

Xin Zhou, Yanru Deng, Caihui Guo, Ying Li, Yuhao Fu, Zhi Wang, Zhanjun Dong

published 22 Jun 2026

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Associations of CYP2B6, CYP2C19, and CYP2D6 isoforms and phenoconversion with sertraline pharmacokinetics

Begoña Tapia-Alzuguren, Covadonga Canga-Espina, Patricio Molero, Azucena Aldaz

published 10 Jun 2026

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Light quality-regulated anthocyanin biosynthesis in Lilium leichtlinii subsp. maximowiczii bulbs: A multi-omics perspective

Jinxing Xu, Shuai Li, Chen Wang, Bingyan Liu, Qi Wu, Yanli Ma, Xinzhu Dai, Yuanhang Zhou, Xinhai Yu, Tianliang Wang

published 13 May 2026

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Unguided web-based brief intervention with genetic risk education to reduce unhealthy alcohol consumption in Japan: Protocol for a randomized controlled trial

Yuki Kono, Mai Tanaka-Sahker, Shino Kikuchi, Yan Luo, Masatsugu Sakata, Ryuhei So, Tamara L. Wall, Toshi A. Furukawa, Ethan Sahker

published 17 Apr 2026

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Effects of increasing molybdenum under low nitrogen input on yield, nitrogen-metabolizing enzymes and nitrogen use efficiency of winter wheat cultivars

Di Yang, Qixia Wu, Youning Wang

published 05 Mar 2026

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Prevalence of polypharmacy and drug interactions in geriatric patients: A cross-sectional study from India

Umaima Farheen Khaiser, Rokeya Sultana, Ranajit Das, Saeed G. Alzahrani, Madhumitha Kannan, Mohammed Khairt Newigy, Mohammed Sharique Ahmed Quadri, Mujeeb Ahmed Shaikh, Farha M. Shaikh, Mohammad Fareed

published 11 Feb 2026

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Biodegradation of polyethylene terephthalate microplastics by Paenibacillus naphthalenovorans PETKKU2: Response surface optimization and genomic evidence for an alternative degradation mechanism

Aophat Choonut, Nantharat Wongfaed, Auraiwan Poolpol, Sophon Boonlue, Kitirote Wantala, Onruthai Pinyakong, Pensri Plangklang, Alissara Reungsang

published 04 Feb 2026

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Development of a CYP2D6-enhanced HepaRG cell model with improved CYP2D6 metabolic capacity

Chizuka Obara, Yohei Iizaka, Akari Mine, Yojiro Anzai, Masako Tada, Shinpei Yamaguchi

published 29 Dec 2025

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Lysine p-nitroanilide impairs cellular energetics and potentiates statin-induced cytotoxicity in RD rhabdomyosarcoma cells

Johan Alvarado-Calderón, Guillermo Juárez-Vega, Jesús Rosendo Martínez-Arellano, Hilda Sánchez-Vidal, Imelda Cecilia Zarzoza-Mendoza, David Morales-Morales, Juan Manuel Germán-Acacio, Rogelio Rodríguez-Sotres, Lilia G. Noriega, José Carlos Páez-Franco

published 04 Dec 2025

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Renal and hepatic function is preserved following inducible knockout of kynurenine pathway enzymes KMO or QPRT in adult mice

Benjamin S. Summers, Luke Milham, Sonia Bustamante, Krishan Gondal, Peggy Rentsch, Gayathri Sundaram, Michael D. Lovelace, Bryce Vissel, Bruce J. Brew

published 04 Dec 2025

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Translocation of benzo(a)pyrene reactive metabolites across human mammary epithelial cell membranes

B. Alex Merrick, Ashley M. Brooks, Julie F. Foley, Betty K. Mansfield, James K. Selkirk

published 03 Dec 2025

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