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Electron cryo-microscopy

Exploration of a workflow for the classification and identification of co-purified protein complexes yields new structures and multiple MSP assembly states

Qingyang Zhang, Abhinandan Venkatesha Murthy, Carsten Mim

published 27 Jan 2026

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Inhibition of HER2 signaling and breast cancer cell growth with a novel antibody targeting HER2 ECD III/IV

Chunchun Liu, Yulei Ren, Xuan Luo, Peiyun Zhou, Xiangjuan Du, Qianmin Wang, Xue Han, Yanhui Xu, Ping Wang, Dan Zhao, Huirong Yang

published 15 Jan 2026

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Substituted cysteine modification and protection indicates selective interactions of the anesthetic photolabel pTFD-di-iPr-BnOH with α+/β– and α+/γ– transmembrane subunit interfaces of synaptic GABA_A receptors

Kieran Bhave, Stuart A. Forman

published 06 Nov 2025

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Molecular basis for the activation of the bitter taste receptor TAS2R14 by Ritonavir

Jiao Wen, Xinyi Ma, Xinyi Zhou, R. Charles Kissell, Yongcheng Lu, Yukyoung Kim, Young Seo Lee, Alice Lee, Shurui Chen, Keman Xu, Leigh D. Plant, Meng Cui

published 19 Sep 2025

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Navigating the unstructured by evaluating alphafold’s efficacy in predicting missing residues and structural disorder in proteins

Sen Zheng

published 25 Mar 2025

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Mechanism of connexin channel inhibition by mefloquine and 2-aminoethoxydiphenyl borate

Pia Lavriha, Yufei Han, Xinyue Ding, Dina Schuster, Chao Qi, Anand Vaithia, Paola Picotti, Volodymyr M. Korkhov

published 31 Dec 2024

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Nematocida displodere mechanosensitive ion channel of small conductance 2 assembles into a unique 6-channel super-structure in vitro

Alexandra Berg, Ronnie P.-A. Berntsson, Jonas Barandun

published 22 Jul 2024

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In silico analysis of TRPM4 variants of unknown clinical significance

Svetlana I. Tarnovskaya, Anna A. Kostareva, Boris S. Zhorov

published 15 Dec 2023

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The structure of a Type III-A CRISPR-Cas effector complex reveals conserved and idiosyncratic contacts to target RNA and crRNA among Type III-A systems

Mohammadreza Paraan, Mohamed Nasef, Lucy Chou-Zheng, Sarah A. Khweis, Allyn J. Schoeffler, Asma Hatoum-Aslan, Scott M. Stagg, Jack A. Dunkle

published 23 Jun 2023

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CryoEM structure of a post-assembly MS-ring reveals plasticity in stoichiometry and conformation

Prashant K. Singh, Gary Cecchini, Terunaga Nakagawa, T. M. Iverson

published 19 May 2023

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Impact of the yeast S0/uS2-cluster ribosomal protein rpS21/eS21 on rRNA folding and the architecture of small ribosomal subunit precursors

Gisela Pöll, Joachim Griesenbeck, Herbert Tschochner, Philipp Milkereit

published 30 Mar 2023

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Cryo-electron microscopy of adipose tissue extracellular vesicles in obesity and type 2 diabetes mellitus

Valentina V. Miroshnikova, Kseniya V. Dracheva, Roman A. Kamyshinsky, Evgeny V. Yastremsky, Luiza A. Garaeva, Irina A. Pobozheva, Sergey B. Landa, Kristina A. Anisimova, Stanislav G. Balandov, Zarina M. Hamid, Dmitriy I. Vasilevsky, Sofya N. Pchelina, Andrey L. Konevega, Tatiana A. Shtam

published 24 Feb 2023

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Structural basis for matriglycan synthesis by the LARGE1 dual glycosyltransferase

Michael Katz, Ron Diskin

published 13 Dec 2022

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