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DNA damage

PRMT5 genetic interactions with DNA double strand break repair genes

Hunter J. Bliss, Juliana Tron, Wesley Bush, Renee A. Bouley, Ruben C. Petreaca

published 09 Oct 2025

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A phosphoramidate modification of FUDR, NUC-3373, causes DNA damage and DAMPs release from colorectal cancer cells, potentiating lymphocyte-induced cell death

Oliver J. Read, Jennifer Bré, Ying Zhang, Peter Mullen, Mustafa Elshani, David J. Harrison

published 16 Sep 2025

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Caliban is a transcriptional target of p53 in response to DNA damage

Jiaqian Cui, Haiyan Zhang, Yan Cheng, Xiaolin Bi, Dong Li

published 28 Aug 2025

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Evaluation of organotin (IV) dithiocarbamate compounds as potential anti-leukemia agents towards CCRF-CEM (CCL-119) cell line: Cytotoxic, apoptotic, cell cycle and genotoxic study

Nabiha Hidayah Abdul Razak, Nur Rasyiqin Rasli, Norsyahira Mohamad Zamri, Asmah Hamid, Normah Awang, Nurul Farahana Kamaludin

published 11 Aug 2025

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An unexpected role of CLASP1 in radiation response and S-phase regulation of head and neck cancer cells

Reinout H. de Roest, Marijke Buijze, Myrthe Veth, Klaas de Lint, Govind Pai, Martin A. Rooimans, Rob M.F. Wolthuis, Arjen Brink, Jos B. Poell, Ruud H. Brakenhoff

published 06 Aug 2025

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Premature termination of DNA Damage Repair by 3-Methyladenine potentiates cisplatin cytotoxicity in nasopharyngeal carcinoma cells

Jie Zhou, Sisi Liu, Jiali Deng, Longmei He, Binyuan Jiang

published 04 Aug 2025

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Resveratrol aggravated H₂O₂-induced the HK-2 cell damage by inhibiting AKT phosphorylation

Shicheng Luo, Yuning Chen, Xuyi Ma, Feng Tian, Xiaozhou He

published 31 Jul 2025

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Environmental relevant concentrations of copper sulphate induce biochemical and molecular toxicity in Labeo rohita

Saima Naz, Riaz Hussain, Hafiz Muhammad Ali, Nasir Masood, Ghazala Jabeen, Rehana Iqbal, Momil Liaquat, Muhammad Irfan Ullah, Kashif Hussain, Tuğçe Merve Berberoğlu, Ahmed A. El-Mansi, Eman A. Elbealy, Abdelalim A. Gadallah, Kasim Sakran Abass

published 28 Jul 2025

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Ferrocene thiazolidine-2,4-dione derivatives cause DNA damage and interfere with DNA repair in triple-negative breast cancer cells

Nyeleti Vukea, Ogunyemi Oderinlo, Matshawandile Tukulula, Setshaba David Khanye, Adrienne Lesley Edkins, Jo-Anne de la Mare

published 17 Jul 2025

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Knockdown of USF1 and USF2 drives prolonged changes in the gene expression response of M12-5B3 cells to DNA damage

Kimberly S. Bellingham-Johnstun, Lisa A. Metzger, Jennifer L. Stone, Kevin Gerrish, Pierre R. Bushel, Michael L. Sikes

published 14 Jul 2025

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HMGB1-BoxA gene therapy in reversing cisplatin resistance in non-small cell lung cancer

Nattapong Puthdee, Van-Hieu Mai, Sirapat Settayanon, Pithi Chanvorachote, Chatchawit Aporntewan, Apiwat Mutirangura, Chanida Vinayanuwattikun

published 25 Jun 2025

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Fatty acid metabolism suppresses neonatal cardiomyocyte proliferation by increasing PDK4 and HMGCS2 expression through PPARδ

Shota Tanaka, Akane Hirota, Yoshiaki Okada, Masanori Obana, Yasushi Fujio

published 08 May 2025

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Zebrafish Polymerase Theta and human Polymerase Theta: Orthologues with homologous function

Corey Thomas, Sydney Green, Lily Kimball, Isaiah R. Schmidtke, Lauren Rothwell, Makayla Griffin, Ivy Par, Sophia Schobel, Yayleene Palacio, Jamie B. Towle-Weicksel, Steven E. Weicksel

published 29 Apr 2025

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