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DNA damage

Matrix stiffness influences drug resistance to gemcitabine analog and AZD 1775 combination in PDAC organoids

Jonathan Barajas, Zhi Yang, Edward Agyare, Xueyou Zhu, Saun-Joo Yoon, Bo Han

published 04 Dec 2025

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In vivo investigation of STN1 downregulation in melanoma formation in adult mice following UV irradiation

Sara Knowles, Fang Wang, Maarten C. Bosland, Shobhan Gaddameedhi, Weihang Chai

published 14 Nov 2025

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PIM1 induces hypoxia-related fibroblast senescence in a mouse model of stress urinary incontinence

Ya Xiao, Mao Chen, Lingyun Li, Liying Chen, Xiaoyu Tian, Xiaoyu Huang, Fangyi Zhu, Bingshu Li, Li Hong

published 12 Nov 2025

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Assessment of DNA damage of smooth muscle cells in tunica media of human arterial allografts using Comet assay method

Miroslava Jandová, Alexander Pilin, Ivan Mazura, Radka Lainková, Ivan Matia, Myroslav Salmay, Pavel Měřička, Ondřej Pecha, Libor Janoušek, Tomáš Grus, Rudolf Špunda, Jaroslav Lindner, Dana Čížková, Jiří Záhora, Miroslav Špaček

published 03 Nov 2025

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Molecular consequences of mitochondrial replacement may be masked from organismal traits in Tigriopus californicus

Jacob R. Denova, Ben A. Flanagan, Murad Jah, Scott L. Applebaum, Suzanne Edmands

published 24 Oct 2025

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The role of lncRNA SNHG15 in UV-induced DNA damage repair

Xin Zhang, Jiahui Lin, Zixuan Fan, Sai Zhang, Meiqi Yang, Tingting Zhu, Qing Lu, Yuming Wang

published 09 Oct 2025

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PRMT5 genetic interactions with DNA double strand break repair genes

Hunter J. Bliss, Juliana Tron, Wesley Bush, Renee A. Bouley, Ruben C. Petreaca

published 09 Oct 2025

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A phosphoramidate modification of FUDR, NUC-3373, causes DNA damage and DAMPs release from colorectal cancer cells, potentiating lymphocyte-induced cell death

Oliver J. Read, Jennifer Bré, Ying Zhang, Peter Mullen, Mustafa Elshani, David J. Harrison

published 16 Sep 2025

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Caliban is a transcriptional target of p53 in response to DNA damage

Jiaqian Cui, Haiyan Zhang, Yan Cheng, Xiaolin Bi, Dong Li

published 28 Aug 2025

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Evaluation of organotin (IV) dithiocarbamate compounds as potential anti-leukemia agents towards CCRF-CEM (CCL-119) cell line: Cytotoxic, apoptotic, cell cycle and genotoxic study

Nabiha Hidayah Abdul Razak, Nur Rasyiqin Rasli, Norsyahira Mohamad Zamri, Asmah Hamid, Normah Awang, Nurul Farahana Kamaludin

published 11 Aug 2025

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An unexpected role of CLASP1 in radiation response and S-phase regulation of head and neck cancer cells

Reinout H. de Roest, Marijke Buijze, Myrthe Veth, Klaas de Lint, Govind Pai, Martin A. Rooimans, Rob M.F. Wolthuis, Arjen Brink, Jos B. Poell, Ruud H. Brakenhoff

published 06 Aug 2025

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Premature termination of DNA Damage Repair by 3-Methyladenine potentiates cisplatin cytotoxicity in nasopharyngeal carcinoma cells

Jie Zhou, Sisi Liu, Jiali Deng, Longmei He, Binyuan Jiang

published 04 Aug 2025

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Resveratrol aggravated H₂O₂-induced the HK-2 cell damage by inhibiting AKT phosphorylation

Shicheng Luo, Yuning Chen, Xuyi Ma, Feng Tian, Xiaozhou He

published 31 Jul 2025

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