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Complement system

Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Preclinical Evaluation and Randomized Phase 1 Clinical Study

Pirow Bekker, Daniel Dairaghi, [ ... ], Thomas J. Schall

siRNA Off-Target Effects Can Be Reduced at Concentrations That Match Their Individual Potency

Daniel R. Caffrey, Juan Zhao, [ ... ], Jason D. Hughes

Active and Passive Immunization Protects against Lethal, Extreme Drug Resistant-Acinetobacter baumannii Infection

Guanpingshen Luo, Lin Lin, [ ... ], Brad Spellberg

Analysis of the Putative Role of CR1 in Alzheimer’s Disease: Genetic Association, Expression and Function

Maria I. Fonseca, Shuhui Chu, [ ... ], Andrea J. Tenner

Plant Sterol Metabolism. Δ⁷-Sterol-C₅-Desaturase (STE1/DWARF7), Δ^5,7-Sterol-Δ⁷-Reductase (DWARF5) and Δ²⁴-Sterol-Δ²⁴-Reductase (DIMINUTO/DWARF1) Show Multiple Subcellular Localizations in Arabidopsis thaliana (Heynh) L

Daniele Silvestro, Tonni Grube Andersen, Hubert Schaller, Poul Erik Jensen

Functional Analyses of Complement Convertases Using C3 and C5-Depleted Sera

Marcin Okroj, Emelie Holmquist, Ben C. King, Anna M. Blom

Quantitative Modeling of the Alternative Pathway of the Complement System

Nehemiah Zewde, Ronald D. Gorham Jr., Angel Dorado, Dimitrios Morikis

Decreased Circulating C3 Levels and Mesangial C3 Deposition Predict Renal Outcome in Patients with IgA Nephropathy

Seung Jun Kim, Hyang Mo Koo, [ ... ], Seung Hyeok Han

Porphyromonas gingivalis FimA Fimbriae: Fimbrial Assembly by fimA Alone in the fim Gene Cluster and Differential Antigenicity among fimA Genotypes

Keiji Nagano, Yoshiaki Hasegawa, [ ... ], Fuminobu Yoshimura

Assembly and Activation of Alternative Complement Components on Endothelial Cell-Anchored Ultra-Large Von Willebrand Factor Links Complement and Hemostasis-Thrombosis

Nancy A. Turner, Joel Moake

Lipopolysaccharide O1 Antigen Contributes to the Virulence in Klebsiella pneumoniae Causing Pyogenic Liver Abscess

Pei-Fang Hsieh, Tzu-Lung Lin, [ ... ], Jin-Town Wang

Alternative Complement Pathway Deregulation Is Correlated with Dengue Severity

Eduardo J. M. Nascimento, Ana M. Silva, [ ... ], Ernesto T. A. Marques

The Major Surface-Associated Saccharides of Klebsiella pneumoniae Contribute to Host Cell Association

Abigail Clements, Fabien Gaboriaud, [ ... ], Richard A. Strugnell

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