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Complement inhibitors

Design and preclinical characterization of ALXN1210: A novel anti-C5 antibody with extended duration of action

Douglas Sheridan, Zhao-Xue Yu, Yuchun Zhang, Rekha Patel, Fang Sun, Melissa A. Lasaro, Keith Bouchard, Bruce Andrien, Andre Marozsan, Yi Wang, Paul Tamburini

published 12 Apr 2018

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The use of the vaccinia virus complement control protein (VCP) in the rat retina

Nilisha Fernando, Riccardo Natoli, Tanja Racic, Yvette Wooff, Jan Provis, Krisztina Valter

published 13 Mar 2018

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Peptide Inhibitor of Complement C1 (PIC1) demonstrates antioxidant activity via single electron transport (SET) and hydrogen atom transfer (HAT)

Magdielis Gregory Rivera, Pamela S. Hair, Kenji M. Cunnion, Neel K. Krishna

published 02 Mar 2018

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MASP-1 of the complement system enhances clot formation in a microvascular whole blood flow model

Lorenz Jenny, József Dobó, Péter Gál, Gábor Pál, Wilbur A. Lam, Verena Schroeder

published 11 Jan 2018

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Human Tamm-Horsfall protein, a renal specific protein, serves as a cofactor in complement 3b degradation

Diana C. J. Rhodes

published 24 Jul 2017

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Inhibition of Myeloperoxidase Activity in Cystic Fibrosis Sputum by Peptide Inhibitor of Complement C1 (PIC1)

Pamela S. Hair, Laura A. Sass, Neel K. Krishna, Kenji M. Cunnion

published 30 Jan 2017

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Complement Activation and STAT4 Expression Are Associated with Early Inflammation in Diabetic Wounds

Kenji M. Cunnion, Neel K. Krishna, Haree K. Pallera, Angela Pineros-Fernandez, Magdielis Gregory Rivera, Pamela S. Hair, Brittany P. Lassiter, Ryan Huyck, Mary A. Clements, Antoinette F. Hood, George T. Rodeheaver, Patrick S. Cottler, Jerry L. Nadler, Anca D. Dobrian

published 20 Jan 2017

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Differential Expression of Complement Markers in Normal and AMD Transmitochondrial Cybrids

Sonali Nashine, Marilyn Chwa, Mina Kazemian, Kunal Thaker, Stephanie Lu, Anthony Nesburn, Baruch D. Kuppermann, M. Cristina Kenney

published 03 Aug 2016

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Quantitative Modeling of the Alternative Pathway of the Complement System

Nehemiah Zewde, Ronald D. Gorham Jr., Angel Dorado, Dimitrios Morikis

published 31 Mar 2016

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Impact of Reducing Complement Inhibitor Binding on the Immunogenicity of Native Neisseria meningitidis Outer Membrane Vesicles

Helene Daniels-Treffandier, Karlijn de Nie, Leanne Marsay, Christina Dold, Manish Sadarangani, Arturo Reyes-Sandoval, Paul R. Langford, David Wyllie, Fergal Hill, Andrew J. Pollard, Christine S. Rollier

published 12 Feb 2016

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Conserved Patterns of Microbial Immune Escape: Pathogenic Microbes of Diverse Origin Target the Human Terminal Complement Inhibitor Vitronectin via a Single Common Motif

Teresia Hallström, Birendra Singh, Peter Kraiczy, Sven Hammerschmidt, Christine Skerka, Peter F. Zipfel, Kristian Riesbeck

published 25 Jan 2016

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Pseudomonas aeruginosa Uses Dihydrolipoamide Dehydrogenase (Lpd) to Bind to the Human Terminal Pathway Regulators Vitronectin and Clusterin to Inhibit Terminal Pathway Complement Attack

Teresia Hallström, Melanie Uhde, Birendra Singh, Christine Skerka, Kristian Riesbeck, Peter F. Zipfel

published 14 Sep 2015

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Peptide Inhibitor of Complement C1 (PIC1) Rapidly Inhibits Complement Activation after Intravascular Injection in Rats

Julia A. Sharp, Pamela S. Hair, Haree K. Pallera, Parvathi S. Kumar, Clifford T. Mauriello, Julius O. Nyalwidhe, Cody A. Phelps, Dalnam Park, Nicole M. Thielens, Stephen M. Pascal, Waldon Chen, Diane M. Duffy, Frank A. Lattanzio, Kenji M. Cunnion, Neel K. Krishna

published 21 Jul 2015

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