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Circulating tumor DNA

Development of a blood test for uterine sarcoma—Diagnosis and monitoring (DOORS-D and DOORS-M) studies

Anna Casey, Rebecca Allsopp, Jacqui Shaw, Caroline Cowley, Elizabeth Stannard, Yvette Griffin, Indrajeet Das, Marc Wadsley, Natalie Darko, Esther L. Moss

published 17 Feb 2026

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Methylation-specific, universal, and highly sensitive identification of ctDNA in prostate cancer by multiplex droplet digital PCR

Søren Kahns, Ahmed H. Zedan, Mads M. Aagaard, Luisa M. D. Canto, Sanne Kjær-Frifeldt, Stine V. Eriksen, Christine V. Madsen, Jonna S. Madsen, Palle J. S. Osther, Torben F. Hansen, Rikke F. Andersen

published 29 Jan 2026

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Feasibility of tumor-informed circulating tumor DNA for detecting minimal residual disease in surgically resected biliary tract cancer

Younghee Park, Kyung Su Kim, Hyunji Jo, Hwang-Phil Kim, Dong Soo Kyung, Youngeun Yoo, Seog Ki Min, Eun Mi Nam, Kyubo Kim

published 21 Jan 2026

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Clinical utility of circulating tumor DNA for early detection of recurrence after curative hepatectomy in patients with colorectal cancer with liver metastases: A prospective observational study protocol (CASSIOPEIA)

Akira Inoue, Yoshihiro Morimoto, Yujiro Nishizawa, Masahiro Hashimoto, Yuki Ozato, Kenta Furukawa, Masashi Hirota, Yasuhiro Miyazaki, Akira Tomokuni, Masaaki Motoori, Kazumasa Fujitani

published 20 Nov 2025

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Study Protocol of SURVIVE HERoes (NCT06643585): Trastuzumab Deruxtecan for molecular relapse in HER2+/ Low early breast cancer with ctDNA positivity after primary therapy

Kerstin Pfister, Thomas W. P. Friedl, Andreas Hartkopf, Franziska Mergel, Sophia Huesmann, Forca Mehmeti, Henning Schäffler, Angelina Fink, Tatjana Braun, Sabine Heublein, Lisa Wiesmüller, Klaus Pantel, Brigitte Rack, Peter A. Fasching, Wolfgang Janni

published 19 Nov 2025

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Analytical validation of a hybrid-approach combining tumor-informed and tumor-agnostic bespoke ctDNA panel assay for the sensitive detection of minimal residual disease

Sunghoon Heo, Seon-Kyu Ham, Hayoon Lee, Bom Han, Hanseong Roh, Seongmun Jeong, Hwang-Phill Kim, Duhee Bang, Sang-Hyun Song, Tae-You Kim

published 10 Nov 2025

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The SURVIVE study (NCT05658172): Bringing breast cancer aftercare to the 21^stcentury: Study protocol of a Phase III clinical trial comparing liquid biopsy guided vs. Standard of care surveillance for intermediate to high-risk breast cancer survivors

Tatjana Braun, Sophia Huesmann, Kerstin Pfister, Thomas W. P. Friedl, Andreas Hartkopf, Klaus Pantel, Forca Mehmeti, Franziska Mergel, Henning Schäffler, Sabine Heublein, Lisa Wiesmüller, Brigitte Rack, Peter A. Fasching, Wolfgang Janni, Angelina Fink

published 09 Sep 2025

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Diagnostic accuracy of circulating tumor DNA for detection of ALK rearrangement in lung cancer: A systematic review and meta-analysis of 14 studies

Jiantong Sun, Lan Yang, Dan Liu, Hui Xue, Panwen Tian, Lei Li

published 25 Aug 2025

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Dissecting cell-free DNA fragmentation variation in tumors using cell line-derived xenograft mouse

Ruiqing Fu, He Amy Su, Yi Zhao, Yafei Tian, Hongyan Chen, Daru Lu

published 15 Jul 2025

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The role of novel biomarkers in the early diagnosis of pancreatic cancer: A systematic review and meta-analysis

Zeyi Zheng, Ziyu Lu, Fei Yan, Yani Song

published 23 May 2025

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The role of renal and liver function in clinical ctDNA testing

Jens Bo Koudahl Conrad, Tenna Vesterman Henriksen, Jesper Berg Nors, Mads Heilskov Rasmussen, Mai-Britt Worm Ørntoft, Nis Hallundbæk Schlesinger, Per Vadgaard Andersen, Kåre Andersson Gotschalck, Claus Lindbjerg Andersen

published 25 Feb 2025

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Repeated rebiopsy for detection of EGFR T790M mutation in patients with advanced-stage lung adenocarcinoma: Associated factors and treatment outcomes of Osimertinib

Taeyun Kim, Junsu Choe, Sun Hye Shin, Byeong-Ho Jeong, Kyungjong Lee, Hojoong Kim, Se-Hoon Lee, Sang-Won Um

published 19 Sep 2024

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Analytical validation of a novel comprehensive genomic profiling informed circulating tumor DNA monitoring assay for solid tumors

Daniel R. Zollinger, Elizabeth Rivers, Alexander Fine, Yanmei Huang, Joseph Son, Akshita Kalyan, Wren Gray, Golshid Baharian, Carly Hammond, Rosalyn Ram, Lindsay Ringman, Dina Hafez, Daniel Savel, Vipul Patel, Marc Dantone, Cui Guo, Merrida Childress, Chang Xu, Dorhyun Johng, Brett Wallden, Prapti Pokharel, William Camara, Priti S. Hegde, Jason Hughes, Corey Carter, Nicole Davarpanah, Viraj Degaonkar, Pratyush Gupta, Sanjeev Mariathasan, Thomas Powles, Sean Ferree, Lucas Dennis, Amanda Young

published 16 May 2024

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