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Cell death

Explainable AI to unveil cellular autophagy dynamics

Oriana Presacan, María Hernández Mesa, Alexandru C. Aldea, Siri Andresen, Amani Al Outa, Julie Aarmo Johannessen, Bogdan Ionescu, Helene Knævelsrud, Michael A. Riegler

published 11 Sep 2025

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Peptidylarginine deiminase 4 deficiency alleviates hypoxia/reoxygenation-induced cardiomyocyte injury

Matthias Mand, Michelle Holthaus, Helmut R. Lieder, Petra Kleinbongard, Lenard Conradi, Thorsten Wahlers, Adnana Paunel-Görgülü

published 10 Sep 2025

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Unraveling the functional landscape of ATRA- and DMSO-differentiated HL-60 cells

Susanna Ghonyan, David Poghosyan, Anush Martirosyan, Sona Margaryan, Aida Avetisyan, Zaruhi Khachatryan, Gayane Manukyan

published 08 Sep 2025

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Vitamin D3 reduces the viability of cancer cells in vitro and retard the EAC tumors growth in mice

Vidya G. Bettada, Chaithanya G. Basavaraju, Shalini H. Doreswamy, SubbaRao V. Tulimilli, Rimshia Naaz, Siva Dallavalasa, Paramahans V. Salimath, Anjali Devi S. Bettadapura, Asha Srinivasan, Rajalakshmi Ramashetty, Suma M. Natraj, SubbaRao V. Madhunapantula

published 08 Sep 2025

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3-O-acetylrubiarbonol B preferentially targets EGFR and MET over rubiarbonol B to inhibit NSCLC cell growth

A-Young Nam, Sang Hoon Joo, Na Yeong Lee, Goo Yoon, Jin Woo Park, MinKyun Na, Jung-Hyun Shim

published 08 Sep 2025

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A novel sulfamoylphenyl-dihydro-thiadiazole derivative as a dual EGFR and carbonic anhydrase inhibitor for cancer therapy

Ibrahim H. Eissa, Hazem Elkady, Walid E. Elgammal, Hazem A. Mahdy, Dalal Z. Husein, Fatma G. Amin, Asmaa A. A. Elsheshiny, Shimaa. S. Abdelfattah, Aisha A. Alsfouk, Eslam B. Elkaeed, Ahmed M. Metwaly

published 04 Sep 2025

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CUB domain-containing protein 1 signaling dysregulates gemcitabine metabolism contributing to therapeutic resistance in T24 cells

Kun-Lin Hsieh, Kuan-Hua Huang, Ching-Ping Chang, Hung-Wen Tsai, Yu-Hao Chang, Yi-Ru Zheng, Huei-Sheng Huang

published 02 Sep 2025

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KFERQ-selective protein autophagy in Caenorhabditis elegans depends on LMP-1

María Gallardo-Campos, Alicia N. Minniti, Juan Hormazabal, Gonzalo Núñez, Carlos F. Lagos, Tomás Perez-Acle, Rebeca Aldunate, Iván E. Alfaro

published 02 Sep 2025

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TGFBR1 gene silencing attenuates cardiomyopathy in the HFpEF mouse model

Xuanyang Shen, Weidong Li, Xiaolu Jiang, Hongfu Wen, Yuan Shen, Wen Zhang, Yongjian Peng, Guoping Kang

published 29 Aug 2025

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Mathematical modelling of tissue growth control by positive and negative feedbacks

Bogdan Kazmierczak, Vitaly Volpert

published 29 Aug 2025

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Caliban is a transcriptional target of p53 in response to DNA damage

Jiaqian Cui, Haiyan Zhang, Yan Cheng, Xiaolin Bi, Dong Li

published 28 Aug 2025

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Exosome-mediated modulation of radioresistance: The radiation-induced bystander effect in prostate cancer cells

Beata Pszczółkowska–Kępa, Wioletta Olejarz, Alicja Głuszko, Grzegorz Wałpuski, Tomasz Lorenc, Beata Brzozowska

published 28 Aug 2025

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Piezo1 regulates autophagy in HT22 hippocampal neurons through the Ca²⁺/Calpain and Calcineurin/TFEB signaling pathways

Yatong Wu, Yan Lu, Hao Zhang, Suhe Dong, Ziqing Zhang, Sinian Wang, Fengsheng Li, Shimin Yin

published 26 Aug 2025

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