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Cell death

Sestrin3 confers resistance to recombinant human arginase in small cell lung cancer by activating Akt/mTOR/ASS1 axis

Zhongqiang Zhang, Zizhe Lin, Weishan Li, Binxiong Chen, Yueming Liu, Hanchao Gao, Shi Xu

published 29 Dec 2025

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Lycopene inhibits ER stress and apoptosis while modulating PI3K/AKT and enhancing antioxidant and anti-apoptotic proteins

Lijun Zheng, Hui Zhang, Yuchao Sun

published 23 Dec 2025

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Therapeutic mechanisms of genistein in ischemic stroke: A systematic review of in vivo and in vitro studies

Nurin Yasmin Mohd Khairudin, Awla Mohd Azraai, Rosfaiizah Siran, Nasibah Azme

published 23 Dec 2025

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Effects of combination therapy of a CDK4/6 and MEK inhibitor in diffuse midline glioma preclinical models

Yusuke Tomita, Gabrielle Link, Yi Ge, Emma R. H. Gold, Anna Racanelli, Herminio Joey Cardona, Megan Romero, Samantha Gadd, Jun Watanabe, Eita Uchida, Rintaro Hashizume, Nozomu Takata, Gonzalo Pinero, Dolores Hambardzumyan, Ivan Spasojevic, Guo Hu, Tammy Hennika, Daniel J. Brat, Adam L. Green, Oren J. Becher

published 22 Dec 2025

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Potential association of certain microRNA gene polymorphisms with recurrent pregnancy loss susceptibility in Saudi women

Aya Rabaa, Afrah Alkuriji, Aishah Kabbi, Samiah Almalki, Zainab Almasawi, Maha Daghestani, Hana Hakami, Jawaher Alzahrani

published 19 Dec 2025

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Overexpression of PTPRCAP inhibits biological function of lung adenocarcinoma through apoptosis pathway

Yuting Yang, Baoshan Zhao, Yingjie Jiang, Xiaoli Han, Jingtao Huang, Guangrui Sun, Zongying Liang

published 18 Dec 2025

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Comprehensive analysis of genes associated with necroptosis and pyroptosis in intestinal ischemia-reperfusion injury

Shuang Bao, YanBo Sun, YiChen Hu, XueFen Lei, YuanPei Zhao, WeiMing Li

published 16 Dec 2025

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The protective influence of Astragalus on rat models of preeclampsia

Lijun Yang, Huiniu Hao, Xinhuan Zhang, Xiaorui Ren, Miao Xu, Nan Zhang, Yudan Zhang, Hailan Yang

published 12 Dec 2025

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Therapeutic mechanism of Pithecellobium clypearia Benth. on imiquimod-induced psoriasis revealed by tissue transcriptomics in mice

Xiyuan He, Yueting Mo, Peixin Shi, Yini Xu, Mingmei Zhou, Ting Zhang

published 12 Dec 2025

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Butyrate ameliorates DSS-induced ulcerative colitis in mice by facilitating autophagy in intestinal epithelial cells and modulating the gut microbiota through blocking the PI3K-AKT-mTOR pathway

Ruifang Li, Yan Sun, Drolma Kelsang, Mingzhi Feng, Hanhui Cai, Jun Zhang

published 11 Dec 2025

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Aotaphenazine, a rare hydrophenazine, targets topoisomerase II with anticancer efficacy: In silico to in vitro evidence

Ahmed M. Metwaly, Ibrahim H. Eissa, Wael M. Afifi, Eslam B. Elkaeed, Aisha A. Alsfouk, Ibrahim M. Ibrahim, Mohamed S. Abdelfattah

published 05 Dec 2025

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Exposure to polystyrene nanoparticles induce disruption of mitochondrial homeostasis and impairs trophoblast cell invasion and migration via MDM2/ROCK1 pathway

Dongdong Hao, Tengteng Ma, Xiaoping Li, Fengchun Gao

published 05 Dec 2025

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Nano-curcumin enhances the sensitivity of tamoxifen-resistant breast cancer cells via the Cyclin D1-DILA1 axis and the PI3K/AKT/mTOR pathway downregulation

Taraneh Givi, Fatemeh Mohajerani, Zahra Moazezi Tehrankhah, Mohammadjavad Karimi Taheri, Maryam Amirahmadi, Sadegh Babashah, Majid Sadeghizadeh

published 05 Dec 2025

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