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Cell death

RIPK3 inhibitor GSK872 targets angiotensin II induced cardiomyocyte hypertrophy by regulating Ca²⁺/ calmodulin dependent protein kinase II

Jingjing Zhang, Huijie Yu, Yuxin Yang, Ajie Liu, Peng Wang

published 07 Jan 2026

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Targeting ceramide metabolism to restore hypoxia-induced apoptosis in p53-deficient colon cancer cells

Karen Mechleb, Nancy Hourani, Maya Fakhry, Osama A. Alyamani, Rouba Hage-Sleiman, Hicham Younes, Antoine Abou Fayad, Nadia Soudani, Amer Sakr, Nadine Darwiche, Georges Nemer, Raya Saab, Marguerite Mrad, Ghassan Dbaibo

published 06 Jan 2026

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Emphasizing the role of oxidative stress and Sirt-1/Nrf2 and TLR-4/NF-κB in Tamarix aphylla mediated neuroprotective potential in rotenone-induced Parkinson’s disease: In silico and in vivo study

Dalia H. Abu-Baih, Abeer H. Elmaidomy, Hesham A. Abou-Zied, Nahla Abdelghany Hussien, Manar I. Rasekh, Entesar A. Saber, Sayed Fouad El-sheikh Ali, Mostafa E. Rateb, Omnia Magdy Hendawy, Faisal H. Altemani, Abdullah H. Altemani, Gerhard Bringmann, Usama Ramadan Abdelmohsen, Omnia Hesham Abdelhafez

published 06 Jan 2026

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Impact of MED12 mutation and CDK8 activity on uterine leiomyoma growth and response to gonadotropin-releasing hormone agonist treatment

Saki Tanioka, Ryoko Asano, Yukihide Ota, Koichi Nagai, Katsuya Takenaka, Taichi Mizushima, Yohei Miyagi, Etsuko Miyagi

published 06 Jan 2026

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Activation and DNA methylation of PANoptosis in polycystic ovary syndrome

Yaguang Han, Yanhua Han, Yuenan Feng, Yuanli Shan, Chang Liu, Kexin Wang, Xiaoke Li, Shidi Zhang, Xiaolin Zhu

published 05 Jan 2026

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Identification of PANoptosis-associated genes in hepatic ischemia-reperfusion injury by integrated bioinformatics analysis and machine learning

Alimu Tulahong, Xinlu Xu, Aimitaji Abulaiti, Talaiti Tuergan, Pingping Qiao, Dalong Zhu, Chang Liu, Rexiati Ruze, Tuerganaili Aji, Yingmei Shao

published 30 Dec 2025

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MicroRNA mediated regulation in early-onset cardiac hypertrophy: Insights from the hypertrophic heart rat model

Shahzad Sadiq, Fadi J. Charchar, Andrew Sanigorski, Tamsyn Crowley, Hansraj R. Bookun, David N. McClure

published 30 Dec 2025

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Green synthesis of zinc oxide nanoparticles using ethanolic leaf extract of Olea europaea and its in vitro evaluation on MDA-MB-231 cancer cell lines, antibacterial and antioxidant activities

Ismaila Ceesay, Pwadubashiyi Coston Pwavodi, Ridwan Olanrewaju Shittu, Huzaifa Umar

published 29 Dec 2025

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Sestrin3 confers resistance to recombinant human arginase in small cell lung cancer by activating Akt/mTOR/ASS1 axis

Zhongqiang Zhang, Zizhe Lin, Weishan Li, Binxiong Chen, Yueming Liu, Hanchao Gao, Shi Xu

published 29 Dec 2025

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Lycopene inhibits ER stress and apoptosis while modulating PI3K/AKT and enhancing antioxidant and anti-apoptotic proteins

Lijun Zheng, Hui Zhang, Yuchao Sun

published 23 Dec 2025

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Therapeutic mechanisms of genistein in ischemic stroke: A systematic review of in vivo and in vitro studies

Nurin Yasmin Mohd Khairudin, Awla Mohd Azraai, Rosfaiizah Siran, Nasibah Azme

published 23 Dec 2025

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Effects of combination therapy of a CDK4/6 and MEK inhibitor in diffuse midline glioma preclinical models

Yusuke Tomita, Gabrielle Link, Yi Ge, Emma R. H. Gold, Anna Racanelli, Herminio Joey Cardona, Megan Romero, Samantha Gadd, Jun Watanabe, Eita Uchida, Rintaro Hashizume, Nozomu Takata, Gonzalo Pinero, Dolores Hambardzumyan, Ivan Spasojevic, Guo Hu, Tammy Hennika, Daniel J. Brat, Adam L. Green, Oren J. Becher

published 22 Dec 2025

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Potential association of certain microRNA gene polymorphisms with recurrent pregnancy loss susceptibility in Saudi women

Aya Rabaa, Afrah Alkuriji, Aishah Kabbi, Samiah Almalki, Zainab Almasawi, Maha Daghestani, Hana Hakami, Jawaher Alzahrani

published 19 Dec 2025

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