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Cell death

Butyrate ameliorates DSS-induced ulcerative colitis in mice by facilitating autophagy in intestinal epithelial cells and modulating the gut microbiota through blocking the PI3K-AKT-mTOR pathway

Ruifang Li, Yan Sun, Drolma Kelsang, Mingzhi Feng, Hanhui Cai, Jun Zhang

published 11 Dec 2025

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Aotaphenazine, a rare hydrophenazine, targets topoisomerase II with anticancer efficacy: In silico to in vitro evidence

Ahmed M. Metwaly, Ibrahim H. Eissa, Wael M. Afifi, Eslam B. Elkaeed, Aisha A. Alsfouk, Ibrahim M. Ibrahim, Mohamed S. Abdelfattah

published 05 Dec 2025

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Exposure to polystyrene nanoparticles induce disruption of mitochondrial homeostasis and impairs trophoblast cell invasion and migration via MDM2/ROCK1 pathway

Dongdong Hao, Tengteng Ma, Xiaoping Li, Fengchun Gao

published 05 Dec 2025

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Nano-curcumin enhances the sensitivity of tamoxifen-resistant breast cancer cells via the Cyclin D1-DILA1 axis and the PI3K/AKT/mTOR pathway downregulation

Taraneh Givi, Fatemeh Mohajerani, Zahra Moazezi Tehrankhah, Mohammadjavad Karimi Taheri, Maryam Amirahmadi, Sadegh Babashah, Majid Sadeghizadeh

published 05 Dec 2025

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Exosomes from bone marrow mesenchymal stem cells protect melanocytes under vitiligo-related conditions through induction of NRF2/HO1 expression

Xuecheng Sun, Bo Huang, Gaobo Ruan, Aie Xu

published 04 Dec 2025

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Autophagy regulates MK-2206-induced LDL receptor expression and cholesterol efflux pathways

Hilde Sundvold, Thea Bismo Strøm

published 04 Dec 2025

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Lysine p-nitroanilide impairs cellular energetics and potentiates statin-induced cytotoxicity in RD rhabdomyosarcoma cells

Johan Alvarado-Calderón, Guillermo Juárez-Vega, Jesús Rosendo Martínez-Arellano, Hilda Sánchez-Vidal, Imelda Cecilia Zarzoza-Mendoza, David Morales-Morales, Juan Manuel Germán-Acacio, Rogelio Rodríguez-Sotres, Lilia G. Noriega, José Carlos Páez-Franco

published 04 Dec 2025

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Human umbilical cord-derived mesenchymal stem cells alleviate autoimmune hepatitis by inhibiting hepatic ferroptosis

Yaqin Li, Bing Liu, Guoxin Hu, Tao Zhou, Xuanqiu He, Ling Guo, Luoshi Zhang, Weizhao Tong, Yihua Chen, Youhua Xu, Guangdong Tong, Wei V. Zheng

published 04 Dec 2025

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Identification of oxidative stress-responsive genes in recurrent miscarriage and their role in disease pathogenesis

Mian Wang, Lingling Zhu, Xiaoyan Cheng

published 02 Dec 2025

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Integrated multi-omics analysis reveals necroptosis-related biomarker BIRC3 for early diagnosis and therapeutic targeting in preeclampsia

Qingxia Lin, Peifeng Huang, Youhong Kang, Yanfeng Lu, Guili Shi

published 01 Dec 2025

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Mechanistic insight into the antidiabetic effects of Ficus hispida fruits: Inhibition of intestinal glucose absorption and pancreatic beta-cell apoptosis

Nusaiba Jahan, Noimul Hasan Siddiquee, Rifayat Ara Khanom Riva, Nur Uddin Chowdhury, Marjanur Rahman Bhuiyan, Khondoker Shahin Ahmed, Hemayet Hossain, Sadikur Rahman Shuvo, AFM. Shahid Ud Daula

published 01 Dec 2025

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Anethole inhibits human U87 Glioma cell proliferation by inducing apoptosis via the PI3K/AKT pathway

Ahmed Abdullah Al Awadh, Elhashimi Eltayb Hassan, Omer Mohamed Shoaib, Osman A.E. Elnoubi, Saadalnour Abusail Mustafa, Yasir Mohammed Althayrayan, Majed Ahmed Althayrayan, Mohammed Merae Alshahrani

published 21 Nov 2025

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LSR overexpression induces chemoresistance in triple negative breast cancer cells through MDR1 upregulation and apoptosis attenuation

Ming Zhao, Zhikun Ma, Amanda B. Parris, Xiaohe Yang

published 03 Nov 2025

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