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Cell binding

A homogeneous SIRPα-CD47 cell-based, ligand-binding assay: Utility for small molecule drug development in immuno-oncology

Teresa L. Burgess, Joshua D. Amason, Jeffrey S. Rubin, Damien Y. Duveau, Laurence Lamy, David D. Roberts, Catherine L. Farrell, James Inglese, Craig J. Thomas, Thomas W. Miller

published 02 Apr 2020

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Humoral immune response to heat shock protein 60 of Aggregatibacter actinomycetemcomitans and cross-reactivity with malondialdehyde acetaldehyde-modified LDL

Mikael Kyrklund, Mika Bildo, Ramin Akhi, Antti E. Nissinen, Pirkko Pussinen, Sohvi Hörkkö, Chunguang Wang

published 25 Mar 2020

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R409K mutation prevents acid-induced aggregation of human IgG4

Hiroshi Namisaki, Seiji Saito, Keiko Hiraishi, Tomoko Haba, Yoshitaka Tanaka, Hideaki Yoshida, Shigeru Iida, Nobuaki Takahashi

published 17 Mar 2020

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Requirement of the acyl-CoA carrier ACBD6 in myristoylation of proteins: Activation by ligand binding and protein interaction

Eric Soupene, Ulrich A. Schatz, Sabine Rudnik-Schöneborn, Frans A. Kuypers

published 27 Feb 2020

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Novel EGFR ectodomain mutations associated with ligand-independent activation and cetuximab resistance in head and neck cancer

Sindhu Nair, Hoa Q. Trummell, Rajani Rajbhandari, Nanda K. Thudi, Susan E. Nozell, Jason M. Warram, Christopher D. Willey, Eddy S. Yang, William J. Placzek, James A. Bonner, Markus Bredel

published 18 Feb 2020

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Selective transmission of some HIV-1 subtype C variants might depend on Envelope stimulating dendritic cells to secrete IL-10

Evelyn Ngwa Lumngwena, Bianca Abrahams, Liliwe Shuping, Claudia Cicala, James Arthos, Zenda Woodman

published 24 Jan 2020

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Structure-function analyses of candidate small molecule RPN13 inhibitors with antitumor properties

Ravi K. Anchoori, Marietta Tan, Ssu-Hsueh Tseng, Shiwen Peng, Ruey-Shyang Soong, Aliyah Algethami, Palmer Foran, Samarjit Das, Chenguang Wang, Tian-Li Wang, Hong Liang, Chien-Fu Hung, Richard B. S. Roden

published 15 Jan 2020

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Sex-specific and opposite modulatory aspects revealed by PPI network and pathway analysis of ischemic stroke in humans

Yan Lv, XY He, Dongguo Li, Tao Liu, GQ Wen, Junfa Li

published 03 Jan 2020

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Binding and functional profiling of antibody mutants guides selection of optimal candidates as antibody drug conjugates

John C. Zwaagstra, Traian Sulea, Jason Baardsnes, Stevo Radinovic, Yuneivy Cepero-Donates, Alma Robert, Maureen D. O’Connor-McCourt, Ilia A. Tikhomirov, Maria Luz. Jaramillo

published 31 Dec 2019

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Analysis of HER2 genomic binding in breast cancer cells identifies a global role in direct gene regulation

Aisling M. Redmond, Soleilmane Omarjee, Igor Chernukhin, Muriel Le Romancer, Jason S. Carroll

published 20 Nov 2019

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Identifying candidate diagnostic markers for early stage of non-small cell lung cancer

Zhen Wu, Xu Zhang, Zhihui He, Liyun Hou

published 14 Nov 2019

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LRRC33 is a novel binding and potential regulating protein of TGF-β1 function in human acute myeloid leukemia cells

Wenjiang Ma, Yan Qin, Bjoern Chapuy, Chafen Lu

published 10 Oct 2019

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Heat shock-induced chaperoning by Hsp70 is enabled in-cell

Drishti Guin, Hannah Gelman, Yuhan Wang, Martin Gruebele

published 26 Sep 2019

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