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Bioengineering

Ectopic expression of Aspergillus flavus uricase and URAT1 in therapeutic cells promotes intracellular degradation of uric acid in hyperuricemic mice

Yuzhong Feng, Jiazhen Cui, Xuan Huang, Yupeng Li, Haolong Dong, Xianghua Xiong, Gang Liu, Qingyang Wang, Huipeng Chen

published 20 Apr 2026

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Dysregulated lactate metabolism synergizes with ALS genetic risk factors to accelerate motor decline

Shweta Tendulkar, Tong Wu, Amy Strickland, Amber R. Hackett, Yurie Sato-Yamada, Xianrong Mao, Yo Sasaki, Jeffrey Milbrandt, A. Joseph Bloom, Aaron DiAntonio

published 17 Apr 2026

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Uptake and determinants of immediate and extended postpartum long-acting reversible contraceptive use in Eastern and Western Africa: A systematic review and meta-analysis

Ritbano Ahmed Abdo, Endalew Gemechu Sendo, Erdaw Tachbele Betre, Kedir Hussen

published 17 Apr 2026

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An explainable multi-head attention network for healthcare IoT threat detection based on the MedDefender-MHAN framework

Ali Alqazzaz

published 17 Apr 2026

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Functional hearing and low frequency hearing preservation after cochlear implant surgery is achievable with FLEX electrode arrays: Real world evidence from the MEHS Registry

Uwe Baumann, Tobias Weissgerber, Andreas Radeloff, Ilona Anderson, Karin A. Koinig, Magdalena Breu, Stefano Morettini, Vera Lohnherr, Joachim Müller, Daniel Polterauer-Neuling

published 17 Apr 2026

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Pretraining effective T5 generative models for clinical and biomedical applications

Saad Althabiti, Chuming Chen, Sultan Alrowili, Cathy Wu, K. Vijay-Shanker

published 17 Apr 2026

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PDGFRα-positive mesenchymal stem/stromal cells contribute to autonomous vascular formation through in-body tissue architecture

Satoru Morikawa, Masaki Yoda, Takehito Ouchi, Takazumi Yasui, Kazumasa Fukuda, Michiru Sugimoto, Rintaro Harada, Tatsuaki Matsumoto, Yo Mabuchi, Osahiko Tsuji, Narihito Nagoshi, Yoshitaka Kase, Hideyuki Okano, Yuko Kitagawa, Masaya Nakamura, Taneaki Nakagawa, Yasuhide Nakayama

published 16 Apr 2026

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Methylviologen resistance in loss-of-function mutants of the polyamine transporter gene OsLAT5

Kyrylo Schenstnyi, Zhengzhi Zhang, Bo Liu, Masayoshi Nakamura, Van Schepler-Luu, Eliza P. I. Loo, Bing Yang, Wolf B. Frommer

published 16 Apr 2026

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Effect of a 3-week program of cane training and use on gait of individuals with Parkinson’s disease: Protocol for a randomized controlled trial

Jordana de Paula Magalhães, Merrill R. Landers, Aline Alvim Scianni, Maria Eduarda Bueno Santos Ribeiro, Christina Danielli Coelho de Morais Faria

published 16 Apr 2026

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Comfort or conservation? Investigating patient choices between plastic and metal speculums

Torren A. Kalaskey, Kathryn G. Quillen, Kyle R. Knutsen, Kylie R. Bushko, Omar F. Dueñas-Garcia

published 15 Apr 2026

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Influences of TiO₂ and SiO₂ nanofillers on the hardness and surface roughness of maxillofacial silicone elastomers after two years of outdoor tropical weathering: An in vitro study

Mohammed Mousa, Belal Elmarhoumy, Mahmoud Salloum, Abdalwhab Zwiri, Mohammed Sghaireen, Thamir Bahattab, Ahmed Almutairi, Njoud Almuzaini, Johari Abdullah

published 15 Apr 2026

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Development and reliability testing of a qualitative observational rating system for individuals with brachial plexus injury performing functional capacity evaluation tests

Tallie M. J. van der Laan, Sietke G. Postema, Corry K. van der Sluis, Michiel F. Reneman

published 13 Apr 2026

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Ventricular activation and repolarization in response to physiological and conventional pacing using ultra-high-frequency electrocardiography

Saúl Palacios, Radovan Smisek, Karol Curila, Uyen Nguyen, Frits W. Prinzen, Josef Halamek, Filip Plesinger, Pavel Jurak, Javier Ramos, Juan Pablo Martínez, Esther Pueyo

published 13 Apr 2026

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