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Binding analysis

Rapid and sensitive detection of gram-negative bacteria using surface-immobilized polymyxin B

Hyun-Jin Kang, Sang-Hoon Lee, Han-Shin Kim, Yong Woo Jung, Hee-Deung Park

published 28 Aug 2023

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Application of In vitro transcytosis models to brain targeted biologics

Kangwen Deng, Yifeng Lu, Sjoerd J. Finnema, Kostika Vangjeli, Junwei Huang, Lili Huang, Andrew Goodearl

published 23 Aug 2023

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How ligands regulate the binding of PARP1 with DNA: Deciphering the mechanism at the molecular level

Kai Wang, Yizhou Wu, Lizhu Lai, Xin Wang, Shuya Sun

published 15 Aug 2023

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Single molecule studies characterize the kinetic mechanism of tetrameric p53 binding to different native response elements

Johannes P. Suwita, Calvin K. Voong, Elina Ly, James A. Goodrich, Jennifer F. Kugel

published 15 Aug 2023

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Global expression pattern of genes containing positively selected sites in European anchovy (Engraulis encrasicolus L.) may shed light on teleost reproduction

Vahap Eldem, Gökmen Zararsız, Melike Erkan

published 11 Aug 2023

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Analytical sameness methodology for the evaluation of structural, physicochemical, and biological characteristics of Armlupeg: A pegfilgrastim biosimilar case study

Arati Deshmukh, Rishank Goyal, Kalyana Sundaram, Kaustubh Dange, Tejshri Lakhote, Sanjay Niranjan, Jennifer Bharucha, Ashok Mishra, Bhavesh Vats, Sanjay Tiwari

published 09 Aug 2023

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Selective DNA-binding of SP120 (rat ortholog of human hnRNP U) is mediated by arginine-glycine rich domain and modulated by RNA

Mary Miyaji, Shinji Kawano, Ryohei Furuta, Emi Murakami, Shogo Ikeda, Kimiko M. Tsutsui, Ken Tsutsui

published 04 Aug 2023

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Analytical comparability to evaluate impact of manufacturing changes of ARX788, an Anti-HER2 ADC in late-stage clinical development

Wayne Yu, Mysore P. Ramprasad, Manoj Pal, Chris Chen, Shashi Paruchuri, Lillian Skidmore, Nick Knudsen, Molly Allen, Ying Buechler

published 10 Jul 2023

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CCX559 is a potent, orally-administered small molecule PD-L1 inhibitor that induces anti-tumor immunity

Kathleen M. C. Sullivan, Marta Vilalta, Linda S. Ertl, Yu Wang, Carolyn Dunlap, Karen Ebsworth, Bin N. Zhao, Shijie Li, Yibin Zeng, Zhenhua Miao, Pingchen Fan, Venkat Mali, Christopher Lange, Darren McMurtrie, Ju Yang, Rebecca Lui, Ryan Scamp, Vicky Chhina, Alice Kumamoto, Simon Yau, Ton Dang, Ashton Easterday, Shirley Liu, Shichang Miao, Israel Charo, Thomas J. Schall, Penglie Zhang

published 07 Jun 2023

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Anti-spike protein to determine SARS-CoV-2 antibody levels: Is there a specific threshold conferring protection in immunocompromised patients?

Philippe Halfon, Sylvie Jordana, Stéphane Blachier, Philippe Cartlamy, Laurent Kbaier, Christina K. Psomas, Patrick Philibert, Gilles Antoniotti, Julie Allemand-Sourrieu, Stanislas Rebaudet, Guilhem Cavaille, Chloé Stavris, Frédérique Retornaz, Laurent Chiche, Guillaume Penaranda

published 28 Apr 2023

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In silico elucidation of potential drug targets against oxygenase domain of Human eNOS Dysfunction

Abbeha Malik, Muhammad Nasir Iqbal, Sidrah Ashraf, Muhammad Saleem Khan, Samar Shahzadi, Muhammad Farhan Shafique, Zureesha Sajid, Muhammad Sajid, Sheikh Arslan Sehgal

published 26 Apr 2023

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Artemisinin suppresses aerobic glycolysis in thyroid cancer cells by downregulating HIF-1a, which is increased by the XIST/miR-93/HIF-1a pathway

Fei Yang, Jie Zhang, Zhijun Zhao, Yan Liu, Zhen Zhao, Kai Fu, Baokun Li, Jing Jin

published 10 Apr 2023

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Characterization of methylation profiles in spontaneous preterm birth placental villous tissue

Heather M. Brockway, Samantha L. Wilson, Suhas G. Kallapur, Catalin S. Buhimschi, Louis J. Muglia, Helen N. Jones

published 23 Mar 2023

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