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Binding analysis

Disulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2)

Felipe de Jesus Cortez, Miyuki Suzawa, [ ... ], Pamela M. England

In Silico Prediction of Mutant HIV-1 Proteases Cleaving a Target Sequence

Jan H. Jensen, Martin Willemoës, Jakob R. Winther, Luca De Vico

Mechanism of Disruption of the Amt-GlnK Complex by P_II-Mediated Sensing of 2-Oxoglutarate

Sarah Maier, Paula Schleberger, [ ... ], Susana L. A. Andrade

CCX559 is a potent, orally-administered small molecule PD-L1 inhibitor that induces anti-tumor immunity

Kathleen M. C. Sullivan, Marta Vilalta, [ ... ], Penglie Zhang

Distinct ET_A Receptor Binding Mode of Macitentan As Determined by Site Directed Mutagenesis

John Gatfield, Celia Mueller Grandjean, [ ... ], Oliver Nayler

A radioligand binding assay for the insulin-like growth factor 2 receptor

Pavlo Potalitsyn, Irena Selicharová, [ ... ], Lenka Žáková

A 2D-QSAR and Grid-Independent Molecular Descriptor (GRIND) Analysis of Quinoline-Type Inhibitors of Akt2: Exploration of the Binding Mode in the Pleckstrin Homology (PH) Domain

Noreen Akhtar, Ishrat Jabeen

Diverse Small Molecule Inhibitors of Human Apurinic/Apyrimidinic Endonuclease APE1 Identified from a Screen of a Large Public Collection

Dorjbal Dorjsuren, Daemyung Kim, [ ... ], Anton Simeonov

Pharmacological and Behavioral Characterization of D-473, an Orally Active Triple Reuptake Inhibitor Targeting Dopamine, Serotonin and Norepinephrine Transporters

Aloke K. Dutta, Soumava Santra, [ ... ], Maarten E. A. Reith

Renal Effects of the Novel Selective Adenosine A₁ Receptor Blocker SLV329 in Experimental Liver Cirrhosis in Rats

Berthold Hocher, Susi Heiden, [ ... ], Thiemo Pfab

Deciphering Ligand Specificity of a Clostridium thermocellum Family 35 Carbohydrate Binding Module (CtCBM35) for Gluco- and Galacto- Substituted Mannans and Its Calcium Induced Stability

Arabinda Ghosh, Ana Sofia Luís, [ ... ], Arun Goyal

Aminoglycosylation Can Enhance the G-Quadruplex Binding Activity of Epigallocatechin

Li-Ping Bai, Hing-Man Ho, [ ... ], Zhi-Hong Jiang

Screening of MITF and SOX10 Regulatory Regions in Waardenburg Syndrome Type 2

Viviane Baral, Asma Chaoui, [ ... ], Nadege Bondurand

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