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Binding analysis

Exploring β-catenin and TCF4 interaction in complex environments by means of novel biosensing platform focal molography

Philipp Cedro, Roman Popov, Maxime Karrer, Jean-Christophe Hau, Eric-André Kusznir, Ralf Thoma, Andreas Frutiger, Matthias Lauer, Sylwia Huber

published 30 Sep 2025

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New chalcone compound exhibits microrna-mediated anticancer properties in glioblastoma

Denis Mustafov, Shoib S. Siddiqui, Shagufta , Irshad Ahmad, Joanne Charlton, Jim Gkantalis, Patricia Rodriguez, Maria Braoudaki

published 26 Sep 2025

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Production of recombinant human G protein-coupled estrogen receptor (GPER) and establishment of a ligand binding assay using graphene quantum dots (GQDs)

Shakhawat Hossain, Md. Forhad Hossain, Md. Sohanur Rahman Sohan, Yuki Omori, Mohammad Tohidul Amin, Toshinobu Tokumoto

published 19 Sep 2025

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Inhibition of LncRNA Kcnq1ot1 suppresses hypoxia-induced pyroptosis of H9C2 cells by regulating miR-27b-3p

Yingjie Yang, Yanchun Ou, Guanlian Mo, Jing Wen, Limin Liang, Shirong Wang, Jinyi Li

published 18 Sep 2025

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Using systems biology and drug repositioning approaches to discover FDA-approved drugs candidates for endometriosis treatment

Samira Sanami, Shahrzad Aghaamoo, Sajjad Ahmad, Ali Fazli, Bahareh Mansouri, Jonas Ivan Nobre Oliveira, Mojgan Rahmanian

published 12 Sep 2025

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Phytochemical and pharmacoinformatics analysis of a traditional antipsoriatic oil formulation for its potential against proinflammatory cytokines TNF-α and IL-17A

Nayak Deeksha Dayanand, Vasudha Devi, Shama Prasada Kabbekodu, Arul Amuthan, Sathish Pai B, Rajasekhar Chinta

published 02 Sep 2025

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Phosphoproteomic profiling of feline mammary carcinoma: Insights into tumor grading and potential therapeutic targets

Pruettha Aruvornlop, Sekkarin Ploypetch, Walasinee Sakcamduang, Sirintra Sirivisoot, Tanit Kasantikul, Sittiruk Roytrakul, Narumon Phaonakrop, Nlin Arya

published 21 Aug 2025

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In vitro detection of canine anti-human antibodies following intratumoral injection of the hu14.18-IL2 immunocytokine in spontaneous canine melanoma

Andrew T. Kosharek, Cindy L. Zuleger, William S. Glass, Jens Eickhoff, Paul M. Sondel, David M. Vail, Mark R. Albertini

published 19 Aug 2025

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Bioorthogonal Non-Canonical Amino Acid Tagging (BONCAT) to detect newly synthesized proteins in cells and their secretome

Elizabeth P. Anim, Justin Mezzanotte, Siwei Chu, Ursula Stochaj

published 14 Aug 2025

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Fermented rice germ extract with high concentration of gamma-aminobutyric acid enhances pentobarbital-induced sleep via GABAergic system in rats

Minsook Ye, Woojin Jeong, Hyo Jeong Yu, Kyoung-min Rheu, Bae-jin Lee, Insop Shim

published 12 Aug 2025

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Structure-based identification of bioactive compounds as trace amine-associated receptor 1 agonists for the therapeutic management of major depressive disorder

Abdelbaset Mohamed Elasbali, Ahmed S. Ali, Mohd Adnan, Taj Mohammad, Anas Shamsi, Md. Imtaiyaz Hassan

published 05 Aug 2025

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Integrated in silico identification of cholinesterase inhibitors from Nyctanthes arbor-tristis

Qazi Mohammad Sajid Jamal, Ali H. Alharbi, Varish Ahmad, Khurshid Ahmad

published 23 Jul 2025

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Computational discovery of potential therapeutic agents against brain-eating amoeba (Naegleria fowleri)

Jacopo Zattoni, Richard F. Ludueña, Maral Aminpour, Jack A. Tuszynski

published 11 Jul 2025

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