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Binding analysis

Analysis of HER2 genomic binding in breast cancer cells identifies a global role in direct gene regulation

Aisling M. Redmond, Soleilmane Omarjee, Igor Chernukhin, Muriel Le Romancer, Jason S. Carroll

published 20 Nov 2019

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Phosphorylation-dependent activity-based conformational changes in P21-activated kinase family members and screening of novel ATP competitive inhibitors

Mehreen Gul, Muhammad Fakhar, Najumuddin, Sajid Rashid

published 18 Nov 2019

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Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids

Qin Huang, Ken Y. Chan, Isabelle G. Tobey, Yujia Alina Chan, Tim Poterba, Christine L. Boutros, Alejandro B. Balazs, Richard Daneman, Jonathan M. Bloom, Cotton Seed, Benjamin E. Deverman

published 14 Nov 2019

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Gene expression profiling of whole blood: A comparative assessment of RNA-stabilizing collection methods

Duncan E. Donohue, Aarti Gautam, Stacy-Ann Miller, Seshamalini Srinivasan, Duna Abu-Amara, Ross Campbell, Charles R. Marmar, Rasha Hammamieh, Marti Jett

published 10 Oct 2019

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Differential scanning fluorimetric analysis of the amino-acid binding to taste receptor using a model receptor protein, the ligand-binding domain of fish T1r2a/T1r3

Takashi Yoshida, Norihisa Yasui, Yuko Kusakabe, Chiaki Ito, Miki Akamatsu, Atsuko Yamashita

published 04 Oct 2019

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Inclusion of enclosed hydration effects in the binding free energy estimation of dopamine D3 receptor complexes

Rajat Kumar Pal, Satishkumar Gadhiya, Steven Ramsey, Pierpaolo Cordone, Lauren Wickstrom, Wayne W. Harding, Tom Kurtzman, Emilio Gallicchio

published 30 Sep 2019

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Heat shock-induced chaperoning by Hsp70 is enabled in-cell

Drishti Guin, Hannah Gelman, Yuhan Wang, Martin Gruebele

published 26 Sep 2019

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A pull-down and slot blot-based screening system for inhibitor compounds of the podoplanin-CLEC-2 interaction

Nobuo Watanabe, Masako Kidokoro, Yusuke Suzuki, Makiko Tanaka, Shigeaki Inoue, Hideo Tsukamoto, Noriaki Hirayama, Pei-Wen Hsieh, Ching-Ping Tseng, Yoshihide Nakagawa, Sadaki Inokuchi

published 25 Sep 2019

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Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma

Kirti Kandhwal Chahal, Jie Li, Irina Kufareva, Milind Parle, Donald L. Durden, Robert J. Wechsler-Reya, Clark C. Chen, Ruben Abagyan

published 20 Sep 2019

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The wing of the ToxR winged helix-turn-helix domain is required for DNA binding and activation of toxT and ompU

Sarah J. Morgan, Emily L. French, Sarah C. Plecha, Eric S. Krukonis

published 09 Sep 2019

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FKBP51 and FKBP12.6—Novel and tight interactors of Glomulin

Andreas Hähle, Thomas M. Geiger, Stephanie Merz, Christian Meyners, Mao Tianqi, Jürgen Kolos, Felix Hausch

published 06 Sep 2019

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Scalable, semi-automated fluorescence reduction neutralization assay for qualitative assessment of Ebola virus-neutralizing antibodies in human clinical samples

Elena N. Postnikova, James Pettitt, Collin J. Van Ryn, Michael R. Holbrook, Laura Bollinger, Shuǐqìng Yú, Yíngyún Caì, Janie Liang, Michael C. Sneller, Peter B. Jahrling, Lisa E. Hensley, Jens H. Kuhn, Mosoka P. Fallah, Richard S. Bennett, Cavan Reilly

published 27 Aug 2019

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Hidden bias in the DUD-E dataset leads to misleading performance of deep learning in structure-based virtual screening

Lieyang Chen, Anthony Cruz, Steven Ramsey, Callum J. Dickson, Jose S. Duca, Viktor Hornak, David R. Koes, Tom Kurtzman

published 20 Aug 2019

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