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Binding analysis

Development of the first in vivo GPR17 ligand through an iterative drug discovery pipeline: A novel disease-modifying strategy for multiple sclerosis

Chiara Parravicini, Davide Lecca, Davide Marangon, Giusy Tindara Coppolino, Simona Daniele, Elisabetta Bonfanti, Marta Fumagalli, Luca Raveglia, Claudia Martini, Elisabetta Gianazza, Maria Letizia Trincavelli, Maria P. Abbracchio, Ivano Eberini

published 22 Apr 2020

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A homogeneous SIRPα-CD47 cell-based, ligand-binding assay: Utility for small molecule drug development in immuno-oncology

Teresa L. Burgess, Joshua D. Amason, Jeffrey S. Rubin, Damien Y. Duveau, Laurence Lamy, David D. Roberts, Catherine L. Farrell, James Inglese, Craig J. Thomas, Thomas W. Miller

published 02 Apr 2020

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PCC0208025 (BMS202), a small molecule inhibitor of PD-L1, produces an antitumor effect in B16-F10 melanoma-bearing mice

Zhengping Hu, Pengfei Yu, Guangying Du, Wenyan Wang, Haibo Zhu, Ning Li, Huijuan Zhao, Zhaoju Dong, Liang Ye, Jingwei Tian

published 26 Mar 2020

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Brain Shuttle Neprilysin reduces central Amyloid-β levels

Christopher R. Campos, Alicia M. Kemble, Jens Niewoehner, Per-Ola Freskgård, Eduard Urich

published 10 Mar 2020

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Assessing the binding properties of the anti-PD-1 antibody landscape using label-free biosensors

Michael E. Brown, Daniel Bedinger, Asparouh Lilov, Palaniswami Rathanaswami, Maximiliano Vásquez, Stéphanie Durand, Ian Wallace-Moyer, Lihui Zhong, Juergen H. Nett, Irina Burnina, Isabelle Caffry, Heather Lynaugh, Melanie Sinclair, Tingwan Sun, John Bukowski, Yingda Xu, Yasmina Noubia Abdiche

published 05 Mar 2020

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Evaluating kratom alkaloids using PHASE

Christopher R. Ellis, Rebecca Racz, Naomi L. Kruhlak, Marlene T. Kim, Alexey V. Zakharov, Noel Southall, Edward G. Hawkins, Keith Burkhart, David G. Strauss, Lidiya Stavitskaya

published 03 Mar 2020

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Lack of an association between clinical INSTI-related body weight gain and direct interference with MC4 receptor (MC4R), a key central regulator of body weight

Carrie McMahon, James L. Trevaskis, Christoph Carter, Kevin Holsapple, Kirsten White, Moupali Das, Sean Collins, Hal Martin, Leigh Ann Burns-Naas

published 28 Feb 2020

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Systematic analysis of the binding behaviour of UHRF1 towards different methyl- and carboxylcytosine modification patterns at CpG dyads

Markus Schneider, Carina Trummer, Andreas Stengl, Peng Zhang, Aleksandra Szwagierczak, M. Cristina Cardoso, Heinrich Leonhardt, Christina Bauer, Iris Antes

published 21 Feb 2020

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Computational study of parameter sensitivity in DevR regulated gene expression

Jagannath Das, Tarunendu Mapder, Sudip Chattopadhyay, Suman K. Banik

published 13 Feb 2020

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RETRACTED: In Silico identification of angiotensin-converting enzyme inhibitory peptides from MRJP1

Rana Adnan Tahir, Afsheen Bashir, Muhammad Noaman Yousaf, Azka Ahmed, Yasmine Dali, Sanaullah Khan, Sheikh Arslan Sehgal

published 03 Feb 2020

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A phenome-wide association study (PheWAS) in the Population Architecture using Genomics and Epidemiology (PAGE) study reveals potential pleiotropy in African Americans

Sarah A. Pendergrass, Steven Buyske, Janina M. Jeff, Alex Frase, Scott Dudek, Yuki Bradford, Jose-Luis Ambite, Christy L. Avery, Petra Buzkova, Ewa Deelman, Megan D. Fesinmeyer, Christopher Haiman, Gerardo Heiss, Lucia A. Hindorff, Chun-Nan Hsu, Rebecca D. Jackson, Yi Lin, Loic Le Marchand, Tara C. Matise, Kristine R. Monroe, Larry Moreland, Kari E. North, Sungshim L. Park, Alex Reiner, Robert Wallace, Lynne R. Wilkens, Charles Kooperberg, Marylyn D. Ritchie, Dana C. Crawford

published 31 Dec 2019

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Binding and functional profiling of antibody mutants guides selection of optimal candidates as antibody drug conjugates

John C. Zwaagstra, Traian Sulea, Jason Baardsnes, Stevo Radinovic, Yuneivy Cepero-Donates, Alma Robert, Maureen D. O’Connor-McCourt, Ilia A. Tikhomirov, Maria Luz. Jaramillo

published 31 Dec 2019

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Verification of hub genes in the expression profile of aortic dissection

Weitie Wang, Qing Liu, Yong Wang, Hulin Piao, Bo Li, Zhicheng Zhu, Dan Li, Tiance Wang, Rihao Xu, Kexiang Liu

published 21 Nov 2019

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