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Binding analysis

Structure-guided screening strategy combining surface plasmon resonance with nuclear magnetic resonance for identification of small-molecule Argonaute 2 inhibitors

Toshimasa Harumoto, Atsuko Sato, Yuki Takayama, Hikaru Miyagi, Jun-ichi Saito, Fumikazu Shinohara

published 31 Jul 2020

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Complementary epitopes and favorable developability of monoclonal anti-LAMP1 antibodies generated using two transgenic animal platforms

Beatrice Cameron, Tarik Dabdoubi, Laurence Berthou-Soulié, Marie Gagnaire, Isabelle Arnould, Anne Severac, Fabienne Soubrier, Jacqueline Morales, Philip A. Leighton, William Harriman, Kathryn Ching, Yasmina Abdiche, Katarina Radošević, Thomas Bouquin

published 16 Jul 2020

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Mechanistic dissection of the PD-L1:B7-1 co-inhibitory immune complex

Sarah C. Garrett-Thomson, Aldo Massimi, Elena V. Fedorov, Jeffrey B. Bonanno, Lisa Scandiuzzi, Brandan Hillerich, Ronald D. Seidel III, James D. Love, Scott J. Garforth, Chandan Guha, Steven C. Almo

published 04 Jun 2020

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An exon skipping screen identifies antitumor drugs that are potent modulators of pre-mRNA splicing, suggesting new therapeutic applications

Yihui Shi, Walter Bray, Alexander J. Smith, Wei Zhou, Joy Calaoagan, Chandraiah Lagisetti, Lidia Sambucetti, Phillip Crews, R. Scott Lokey, Thomas R. Webb

published 29 May 2020

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Characterization of histone modification patterns and prediction of novel promoters using functional principal component analysis

Mijeong Kim, Shili Lin

published 27 May 2020

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The aroma of TEMED as an activation and stabilizing signal for the antibacterial enzyme HEWL

Zahra Seraj, Shahin Ahmadian, Matthew R. Groves, Arefeh Seyedarabi

published 19 May 2020

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Sequence-structure-function relationships in class I MHC: A local frustration perspective

Onur Serçinoğlu, Pemra Ozbek

published 18 May 2020

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Seroprevalence of three paramyxoviruses; Hendra virus, Tioman virus, Cedar virus and a rhabdovirus, Australian bat lyssavirus, in a range expanding fruit bat, the Grey-headed flying fox (Pteropus poliocephalus)

Wayne S. J. Boardman, Michelle L. Baker, Victoria Boyd, Gary Crameri, Grantley R. Peck, Terry Reardon, Ian G. Smith, Charles G. B. Caraguel, Thomas A. A. Prowse

published 06 May 2020

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Effect of linker on the binding free energy of stapled p53/HDM2 complex

Haeri Im, Sihyun Ham

published 30 Apr 2020

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The L motifs of two moss pentatricopeptide repeat proteins are involved in RNA editing but predominantly not in RNA recognition

Takuya Matsuda, Mamoru Sugita, Mizuho Ichinose

published 29 Apr 2020

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Development of the first in vivo GPR17 ligand through an iterative drug discovery pipeline: A novel disease-modifying strategy for multiple sclerosis

Chiara Parravicini, Davide Lecca, Davide Marangon, Giusy Tindara Coppolino, Simona Daniele, Elisabetta Bonfanti, Marta Fumagalli, Luca Raveglia, Claudia Martini, Elisabetta Gianazza, Maria Letizia Trincavelli, Maria P. Abbracchio, Ivano Eberini

published 22 Apr 2020

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A homogeneous SIRPα-CD47 cell-based, ligand-binding assay: Utility for small molecule drug development in immuno-oncology

Teresa L. Burgess, Joshua D. Amason, Jeffrey S. Rubin, Damien Y. Duveau, Laurence Lamy, David D. Roberts, Catherine L. Farrell, James Inglese, Craig J. Thomas, Thomas W. Miller

published 02 Apr 2020

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PCC0208025 (BMS202), a small molecule inhibitor of PD-L1, produces an antitumor effect in B16-F10 melanoma-bearing mice

Zhengping Hu, Pengfei Yu, Guangying Du, Wenyan Wang, Haibo Zhu, Ning Li, Huijuan Zhao, Zhaoju Dong, Liang Ye, Jingwei Tian

published 26 Mar 2020

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