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Binding analysis

Mechanistic dissection of the PD-L1:B7-1 co-inhibitory immune complex

Sarah C. Garrett-Thomson, Aldo Massimi, [ ... ], Steven C. Almo

An exon skipping screen identifies antitumor drugs that are potent modulators of pre-mRNA splicing, suggesting new therapeutic applications

Yihui Shi, Walter Bray, [ ... ], Thomas R. Webb

Characterization of histone modification patterns and prediction of novel promoters using functional principal component analysis

Mijeong Kim, Shili Lin

The aroma of TEMED as an activation and stabilizing signal for the antibacterial enzyme HEWL

Zahra Seraj, Shahin Ahmadian, Matthew R. Groves, Arefeh Seyedarabi

Sequence-structure-function relationships in class I MHC: A local frustration perspective

Onur Serçinoğlu, Pemra Ozbek

Seroprevalence of three paramyxoviruses; Hendra virus, Tioman virus, Cedar virus and a rhabdovirus, Australian bat lyssavirus, in a range expanding fruit bat, the Grey-headed flying fox (Pteropus poliocephalus)

Wayne S. J. Boardman, Michelle L. Baker, [ ... ], Thomas A. A. Prowse

Effect of linker on the binding free energy of stapled p53/HDM2 complex

Haeri Im, Sihyun Ham

The L motifs of two moss pentatricopeptide repeat proteins are involved in RNA editing but predominantly not in RNA recognition

Takuya Matsuda, Mamoru Sugita, Mizuho Ichinose

Development of the first in vivo GPR17 ligand through an iterative drug discovery pipeline: A novel disease-modifying strategy for multiple sclerosis

Chiara Parravicini, Davide Lecca, [ ... ], Ivano Eberini

A homogeneous SIRPα-CD47 cell-based, ligand-binding assay: Utility for small molecule drug development in immuno-oncology

Teresa L. Burgess, Joshua D. Amason, [ ... ], Thomas W. Miller

PCC0208025 (BMS202), a small molecule inhibitor of PD-L1, produces an antitumor effect in B16-F10 melanoma-bearing mice

Zhengping Hu, Pengfei Yu, [ ... ], Jingwei Tian

Brain Shuttle Neprilysin reduces central Amyloid-β levels

Christopher R. Campos, Alicia M. Kemble, [ ... ], Eduard Urich

Assessing the binding properties of the anti-PD-1 antibody landscape using label-free biosensors

Michael E. Brown, Daniel Bedinger, [ ... ], Yasmina Noubia Abdiche

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