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Antimalarials

The monoterpene 1,8-cineole prevents cerebral edema in a murine model of severe malaria

Edgleyson C. dos Santos, Leandro S. Silva, Alessandro S. Pinheiro, Douglas E. Teixeira, Diogo B. Peruchetti, Rodrigo P. Silva-Aguiar, Camila H. C. Wendt, Kildare R. Miranda, Andrelina N. Coelho-de-Souza, José Henrique Leal-Cardoso, Celso Caruso-Neves, Ana Acacia S. Pinheiro

published 12 May 2022

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Survival of HT29 cancer cells is influenced by hepatocyte growth factor receptor inhibition through modulation of self-DNA-triggered TLR9-dependent autophagy response

Bettina Bohusné Barta, Ágnes Simon, Lőrinc Nagy, Titanilla Dankó, Regina Eszter Raffay, Gábor Petővári, Viktória Zsiros, Anna Sebestyén, Ferenc Sipos, Györgyi Műzes

published 12 May 2022

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Prevalence of arps10, fd, pfmdr-2, pfcrt and pfkelch13 gene mutations in Plasmodium falciparum parasite population in Uganda

Moses Ocan, Fred Katabazi Ashaba, Savannah Mwesigwa, Kigozi Edgar, Moses R. Kamya, Sam L. Nsobya

published 05 May 2022

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Evaluation of blood cell count parameters as predictors of treatment failure of malaria in Angola: An observational study

Euclides Nenga Manuel Sacomboio, Cruz dos Santos Sebastião, Silvana Teresa da Costa Salvador, Joaquim António João, Daisy Viviana Sebastião Bapolo, Ngiambudulu M. Francisco, Joana Morais, Eduardo Ekundi Valentim

published 05 May 2022

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Chloroquine and COVID-19—A systems biology model uncovers the drug’s detrimental effect on autophagy and explains its failure

Orsolya Kapuy, Tamás Korcsmáros

published 07 Apr 2022

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Therapeutic efficacy of artemether-lumefantrine, artesunate-amodiaquine and dihydroartemisinin-piperaquine in the treatment of uncomplicated Plasmodium falciparum malaria in Sub-Saharan Africa: A systematic review and meta-analysis

Karol Marwa, Anthony Kapesa, Vito Baraka, Evelyne Konje, Benson Kidenya, Jackson Mukonzo, Erasmus Kamugisha, Gote Swedberg

published 10 Mar 2022

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Molecular profiling of the artemisinin resistance Kelch 13 gene in Plasmodium falciparum from Nigeria

Fehintola V. Ajogbasile, Paul E. Oluniyi, Adeyemi T. Kayode, Kazeem O. Akano, Benjamin B. Adegboyega, Courage Philip, Nnenna Ogbulafor, Henrietta U. Okafor, Stephen Oguche, Robinson D. Wammanda, Olugbenga A. Mokuolu, Onikepe A. Folarin, Christian T. Happi

published 28 Feb 2022

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Considerations and practical implications of performing a phenotypic CRISPR/Cas survival screen

Ator Ashoti, Francesco Limone, Melissa van Kranenburg, Anna Alemany, Mirna Baak, Judith Vivié, Frederica Piccioni, Pascale F. Dijkers, Menno Creyghton, Kevin Eggan, Niels Geijsen

published 17 Feb 2022

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A PDK-1 allosteric agonist neutralizes insulin signaling derangements and beta-amyloid toxicity in neuronal cells and in vitro

Henry Querfurth, John Marshall, Keykavous Parang, Mengia S. Rioult-Pedotti, Rakesh Tiwari, Bumsup Kwon, Steve Reisinger, Han-Kyu Lee

published 21 Jan 2022

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Effect of adverse events on non-adherence and study non-completion in malaria chemoprevention during pregnancy trial: A nested case control study

Noel Patson, Mavuto Mukaka, Ingrid Peterson, Titus Divala, Lawrence Kazembe, Don Mathanga, Miriam K. Laufer, Tobias Chirwa

published 19 Jan 2022

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Proteomics-based screening and antibiotic resistance assessment of clinical and sub-clinical Brucella species: An evolution of brucellosis infection control

Ayman Elbehiry, Musaad Aldubaib, Osamah Al Rugaie, Eman Marzouk, Marwan Abaalkhail, Ihab Moussa, Mohamed H. El-Husseiny, Adil Abalkhail, Mohammed Rawway

published 13 Jan 2022

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In search of autophagy biomarkers in breast cancer: Receptor status and drug agnostic transcriptional changes during autophagy flux in cell lines

Francesca Mascia, Ilya Mazo, Wei-Lun Alterovitz, Konstantinos Karagiannis, Wells W. Wu, Rong-Fong Shen, Julia A. Beaver, V. Ashutosh Rao

published 06 Jan 2022

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MHC class I antigen cross-presentation mediated by PapMV nanoparticles in human antigen-presenting cells is dependent on autophagy

David Possamaï, Laïla-Aïcha Hanafi, Angélique Bellemare-Pelletier, Katia Hamelin, Paméla Thébault, Marie-Josée Hébert, Étienne Gagnon, Denis Leclerc, Réjean Lapointe

published 31 Dec 2021

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