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Antibody therapy

Human resistin is critical to activation of the NLRP3 inflammasome in macrophages

Udeshika Kariyawasam, Winson Lam, John Skinner, Rituparna Chakrabarti, Andrea Cox, Paul M. Hassoun, Qing Lin, Roger A. Johns

published 10 Apr 2026

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Mode of action-specific and cause-specific retention of biologic and targeted synthetic disease-modifying antirheumatic drugs in anti-SS-A antibody-positive rheumatoid arthritis: The ANSWER cohort study

Kazuma Nishisaka, Takaichi Okano, Takumi Imai, Masanori Tsubosaka, Tomoyuki Kamenaga, Naoki Nakano, Shinya Hayashi, Wataru Yamamoto, Akira Onishi, Kosaku Murakami, Kohei Tsujimoto, Masao Katsushima, Ayaka Yoshikawa, Takuya Kotani, Hideki Amuro, Yonsu Son, Tetsu Itami, Yuji Nozaki, Yoko Nose, Mai Yamashita, Iku Shirasugi, Hirotaka Yamada, Keisuke Nishimura, Yo Ueda, Sho Sendo, Motomu Hashimoto, Ryosuke Kuroda, Jun Saegusa

published 18 Mar 2026

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Clinical proof of concept for small molecule mediated inhibition of IL-17 in psoriasis

Richard B. Warren, Hamish J. A. Hunter, Kim A. Papp, Kenneth B. Gordon, Meina T. Tang, Jeffrey V. Enejosa, Kuan-Chieh Huang, Debasish Raha, Hashini M. Batugedara, Craig Skinner, Philip A. Kobel, Peter M. Rademacher, Nico Ghilardi, Paul Fatheree, John R. Jacobsen, Timothy T. Lu

published 23 Jan 2026

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Clinical characteristics, diagnostic modalities, and therapeutic strategies of spontaneous renal artery dissection: A systematic review and diagnostic analysis

Jiahao Zhu, Zengqiang Xu, Yang Geng, Mengxin Jiang, Chang Xu, Yingjiang Xu

published 23 Jan 2026

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Inhibition of HER2 signaling and breast cancer cell growth with a novel antibody targeting HER2 ECD III/IV

Chunchun Liu, Yulei Ren, Xuan Luo, Peiyun Zhou, Xiangjuan Du, Qianmin Wang, Xue Han, Yanhui Xu, Ping Wang, Dan Zhao, Huirong Yang

published 15 Jan 2026

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The combination of LILRB4-targeting NK cell engagers and cGAS–STING agonists enhances the anti–multiple myeloma immune activity of NK cells

Meng Li, Yuwei Zhao, Lizhou Zhao, Xue Chen, Jianxun Kang, Aiping Tong, Chen Yang, Ping Wang, Minjun Yang, Kejiang Wang, Jialiang Gao, Ying Li, Xuemei Fu

published 19 Dec 2025

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Characterization of anti-canine CD20 antibody 4E1-7-B_f and comparison with commercially available anti-human CD20 antibodies

Takuya Mizuno, Yukinari Kato, Toshihiro Tsukui, Masaya Igase

published 27 Jun 2025

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Experiences of recently diagnosed urban COVID-19 outpatients: A survey on patient worries, provider-patient interactions, and neutralizing monoclonal antibody treatment

Lindsey E. Fish, Samantha C. Roberts, Tellen D. Bennett, Nichole E. Carlson, Mika K. Hamer, Bethany M. Kwan, Seth Russell, Adane F. Wogu, Matthew K. Wynia, Adit A. Ginde

published 23 Jun 2025

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Long-term anti-SARS-CoV-2 antibody trajectories after neutralizing monoclonal antibody treatment

Elizabeth S. Munroe, Greg A. Grandits, Robert C. Hyzy, Hallie C. Prescott, Thomas W. Barrett, Robin L. Dewar, Nicole Engen, Anna L. Goodman, Timothy J. Hatlen, Helene Highbarger, Thomas L. Holland, Gareth Hughes, Tomas O. Jensen, Muhammad A. Khan, Ioannis Kalomenidis, Nayon Kang, Sylvain Laverdure, Prasad Manian, Vidya Menon, Ravi Patel, Srikanth Ramachandruni, Tauseef Rehman, Kathryn Shaw-Saliba, Birgit Thorup Røge, David M. Vock, Amy C. Weintrob, Barnaby E. Young, Anne P. Frosch, for the STRIVE Network and Therapeutics for Inpatients with COVID-19 (TICO) study groups

published 18 Jun 2025

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A human antibody specific for SIRPα reprograms macrophages and promotes antibody mediated anti-cancer activity

Keifer G. Kurtz, Irina Lebedeva, Stephanie A. Pierre, David Andrew, Yu-Rou Liao, Daisy Ambriz, Olivia Vergnolle, Leyi Shen, Elizabeth Nyakatura, Manuel Baca, David A. Scheinberg

published 23 May 2025

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ABT-263, a BCL-2 inhibitor, selectively eliminates latently HIV-1-infected cells without viral reactivation

Jeong Eun Kang, Hyun Wook Seo, Dong-Eun Kim, Young Hyun Shin, Songmee Bae, Cheol-Hee Yoon

published 20 May 2025

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CD38-targeted attenuated interferon alpha immunocytokine activates both innate and adaptive immune cells to drive anti-tumor activity

James F. Sampson, Hong Zhang, Dongmei Zhang, Mingying Bi, Adam Hinthorne, Sakeena Syed, Yuhong Zhang, Nibedita Chattopadhyay, Sabrina Collins, Sarah Pogue, Pia Björck, Michael Curley

published 02 May 2025

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Measles neutralising antibody levels in patients receiving intravenous immunoglobulin treatment – a sub-analysis of a randomized, cross-over bioequivalence trial

Vatsala Rajendram, Martyn Paddick, John More

published 07 Feb 2025

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