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Adjustment of dosage at steady state

Pharmacokinetics of Dolutegravir, nucleoside analogues, and intracellular metabolites using plasma separation cards: A comparative analysis with traditional sampling methods in healthy volunteers

Beth Thompson, Laura J. Else, Laura Dickinson, Stacey Edick, Ashley Zyhowski, Ken Ho, Leslie Meyn, Sujan Dilly-Penchala, Victoria Shaw, Ian McGowan, Saye Khoo, Rhonda M. Brand

published 23 Jan 2026

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Clinical proof of concept for small molecule mediated inhibition of IL-17 in psoriasis

Richard B. Warren, Hamish J. A. Hunter, Kim A. Papp, Kenneth B. Gordon, Meina T. Tang, Jeffrey V. Enejosa, Kuan-Chieh Huang, Debasish Raha, Hashini M. Batugedara, Craig Skinner, Philip A. Kobel, Peter M. Rademacher, Nico Ghilardi, Paul Fatheree, John R. Jacobsen, Timothy T. Lu

published 23 Jan 2026

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Phase 1, randomized, crossover study comparing intravenous GTX-104 to oral nimodipine in healthy human subjects

Amresh Kumar, Carrie D’Andrea, Prashant Kohli, S. George Kottayil, James Longstreth, R. Loch Macdonald

published 08 Dec 2025

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Population pharmacokinetic modeling of missed mycophenolate mofetil doses: Impact on exposure and exploration of mitigation strategies

Franck Maizaud, Selim Arraki-Zava, Hamza Sayadi, Yeleen Fromage, Pierre Marquet, Jean-Baptiste Woillard, Caroline Monchaud

published 28 Aug 2025

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Bifurcation study of a tumor-immune system with chemotherapy

Abdelhamid Ajbar, Rubayyi T. Alqahtani, Khalid Alhumaizi

published 03 Jul 2025

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Optimizing CMV therapy: Population pharmacokinetics and Monte Carlo simulations for letermovir and maribavir dosage

Yeleen Fromage, Hamza Sayadi, Sophie Alain, Pierre Marquet, Gilles Peytavin, Jean-Baptiste Woillard

published 28 Apr 2025

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Update on a brain-penetrant cardiac glycoside that can lower cellular prion protein levels in human and guinea pig paradigms

Shehab Eid, Wenda Zhao, Declan Williams, Zahra Nasser, Jennifer Griffin, Pavel Nagorny, Gerold Schmitt-Ulms

published 24 Sep 2024

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Population pharmacokinetics of voriconazole and the role of CYP2C19 genotype on treatment optimization in pediatric patients

Lin Hu, Shiqiong Huang, Qi Huang, Juanjuan Huang, Zeying Feng, Gefei He

published 11 Sep 2023

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The influence of metformin transporter gene SLC22A1 and SLC47A1 variants on steady-state pharmacokinetics and glycemic response

Vitarani Dwi Ananda Ningrum, Ahmad Hamim Sadewa, Zullies Ikawati, Rika Yuliwulandari, M. Robikhul Ikhsan, Rohmatul Fajriyah

published 29 Jul 2022

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Utilizing virtual experiments to increase understanding of discrepancies involving in vitro-to-in vivo predictions of hepatic clearance

Preethi Krishnan, Andrew K. Smith, Glen E. P. Ropella, Lopamudra Dutta, Ryan C. Kennedy, C. Anthony Hunt

published 22 Jul 2022

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Gender-based differences in brain and plasma pharmacokinetics of letrozole in sprague-dawley rats: Application of physiologically-based pharmacokinetic modeling to gain quantitative insights

Priyanka Arora, Gary Gudelsky, Pankaj B. Desai

published 02 Apr 2021

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L-arginine effects on cerebrovascular reactivity, perfusion and neurovascular coupling in MELAS (mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes) syndrome

Lance H. Rodan, Julien Poublanc, Joseph A. Fisher, Olivia Sobczyk, David J. Mikulis, Ingrid Tein

published 03 Sep 2020

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Determination of metformin bio-distribution by LC-MS/MS in mice treated with a clinically relevant paradigm

Kiran Chaudhari, Jianmei Wang, Yong Xu, Ali Winters, Linshu Wang, Xiaowei Dong, Eric Y. Cheng, Ran Liu, Shao-Hua Yang

published 11 Jun 2020

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