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Open Access

Correction

Correction: Potential therapeutic impact of CD13 expression in non-small cell lung cancer

  • Lars Henning Schmidt,
  • Caroline Brand,
  • Janine Stucke-Ring,
  • Christoph Schliemann,
  • Torsten Kessler,
  • Saliha Harrach,
  • Michael Mohr,
  • Dennis Görlich,
  • Alessandro Marra,
  • Ludger Hillejan,
  • Carsten Müller-Tidow,
  • Georg Lenz,
  • Eva Wardelmann,
  • Rainer Wiewrodt,
  • Wolfgang E. Berdel,
  • Christian Schwöppe,
  •  [ ... ],
  • Wolfgang Hartmann
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Fig 3 appears incorrectly. Please see the complete, correct Fig 3 here.

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Fig 3. In vivo therapeutic activity of systemic tTF-NGR against CD13+ A549 tumor xenografts.

To investigate CD13 expression flow cytometry was performed with a monoclonal PE-labeled anti-CD13 antibody. CD13 expression was found in 47% of the A549 lung cancer cells (green, control; purple, CD13) (Fig 3A). Following treatment with tTF-NGR (1 mg tTF-NGR/kg x5 (arrows); i.v.; n = 4 CD-1 nude mice) tumor growth of subcutaneous A549 xenotransplants was reduced as compared to the saline control group (n = 6) CD-1 nude mice (Fig 3B). The CD13 expression in subcutaneous A549 xenotransplant is demonstrated by immunofluorescence; since the antibodies used for CD13 and CD31 staining are speciesspecific for human CD13 and CD31, vascular and perivascular staining were not assayed in the xenografts (Fig 3C).

https://doi.org/10.1371/journal.pone.0183201.g001

Reference

  1. 1. Schmidt LH, Brand C, Stucke-Ring J, Schliemann C, Kessler T, Harrach S, et al. (2017) Potential therapeutic impact of CD13 expression in non-small cell lung cancer. PLoS ONE 12(6): e0177146. pmid:28604784

Citation: Schmidt LH, Brand C, Stucke-Ring J, Schliemann C, Kessler T, Harrach S, et al. (2017) Correction: Potential therapeutic impact of CD13 expression in non-small cell lung cancer. PLoS ONE 12(8): e0183201. https://doi.org/10.1371/journal.pone.0183201

Published: August 9, 2017

Copyright: © 2017 Schmidt et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.