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Correction: Potential therapeutic impact of CD13 expression in non-small cell lung cancer

  • Lars Henning Schmidt,
  • Caroline Brand,
  • Janine Stucke-Ring,
  • Christoph Schliemann,
  • Torsten Kessler,
  • Saliha Harrach,
  • Michael Mohr,
  • Dennis Görlich,
  • Alessandro Marra,
  • Ludger Hillejan,
  • Carsten Müller-Tidow,
  • Georg Lenz,
  • Eva Wardelmann,
  • Rainer Wiewrodt,
  • Wolfgang E. Berdel,
  • Christian Schwöppe,
  •  [ ... ],
  • Wolfgang Hartmann
  • [ view all ]
  • [ view less ]

Correction: Potential therapeutic impact of CD13 expression in non-small cell lung cancer

  • Lars Henning Schmidt, 
  • Caroline Brand, 
  • Janine Stucke-Ring, 
  • Christoph Schliemann, 
  • Torsten Kessler, 
  • Saliha Harrach, 
  • Michael Mohr, 
  • Dennis Görlich, 
  • Alessandro Marra, 
  • Ludger Hillejan
PLOS
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Fig 3 appears incorrectly. Please see the complete, correct Fig 3 here.

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Fig 3. In vivo therapeutic activity of systemic tTF-NGR against CD13+ A549 tumor xenografts.

To investigate CD13 expression flow cytometry was performed with a monoclonal PE-labeled anti-CD13 antibody. CD13 expression was found in 47% of the A549 lung cancer cells (green, control; purple, CD13) (Fig 3A). Following treatment with tTF-NGR (1 mg tTF-NGR/kg x5 (arrows); i.v.; n = 4 CD-1 nude mice) tumor growth of subcutaneous A549 xenotransplants was reduced as compared to the saline control group (n = 6) CD-1 nude mice (Fig 3B). The CD13 expression in subcutaneous A549 xenotransplant is demonstrated by immunofluorescence; since the antibodies used for CD13 and CD31 staining are speciesspecific for human CD13 and CD31, vascular and perivascular staining were not assayed in the xenografts (Fig 3C).

https://doi.org/10.1371/journal.pone.0183201.g001

Reference

  1. 1. Schmidt LH, Brand C, Stucke-Ring J, Schliemann C, Kessler T, Harrach S, et al. (2017) Potential therapeutic impact of CD13 expression in non-small cell lung cancer. PLoS ONE 12(6): e0177146. pmid:28604784