PONE-D-24-24217Identification and Validation of ATP6V1G1-regulated Phosphorylated Proteins in Hepatocellular CarcinomaPLOS ONE

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Additional Editor Comments:

The manuscript reported the effect of ATP6V1G1 in HCC and protein expression associated with of ATP6V1G1 activity. The phosphorylated proteins regulated by ATP6V1G1 in HCC were identified by phosphoproteomics and LC-MS/MS analysis. How did the phosphorylated proteins (DEPPs) contribute to the protein expression? How was the impact of ATP6V1G1 on tumor progression deduced based on the present studies? More alternate studies are needed to provide supportive data prior to drawing a convincing conclusion. How do the present results contribute to the mechanistic action of cancer development?

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Submitted filename: Comments.pdf

Identification and Validation of ATP6V1G1-regulated Phosphorylated Proteins in Hepatocellular Carcinoma

PONE-D-24-24217R1

Dear Dr. Chen,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

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Kind regards,

John Wing Shing Ho

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

The manuscript has been sufficiently improved and is acceptable.

Reviewers' comments: