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Are you ready to submit your manuscript? Please review the submission guidelineseditorial and publishing policiesfigure guidelines, and table guidelines, and then refer to this checklist to ensure that you have gathered all the relevant information and that the manuscript is formatted appropriately.

Submission Instructions

These are step-by-step instructions for submitting a manuscript to our online submission system.

Do not resubmit your manuscript if you have otherwise already submitted it to PLOS ONE. If you are submitting a revised manuscript, read the revision guidelines. If you are responding to a technical check inquiry, follow the instructions you receive by email from PLOS staff.

Keep this page open for your reference as you move through the submission process.

  Before you submit, refer to our sample files to ensure that your submission meets our formatting requirements:


Sign in to our submission system.

Submit new manuscript

Click on the “Submit New Manuscript” link under the “New Submissions” heading. This will take you to a new screen.

Article type

Next, select your article type. Most submissions will be either a Research Article or a Clinical Trial.


Enter the title and short title of your manuscript. Please enter your titles in sentence case (capitalize only the first word of the title, the first word of the subtitle, and any proper nouns and genus names). Do not enter titles in all capital letters.


Next you will be asked to enter the names, email addresses, and institutional affiliations for each author. Each author should have made real and concrete contributions to the manuscript; you will have the opportunity to describe each author’s contribution in a further step. Each author should also be aware of the submission and approve the manuscript submitted. PLOS does not condone or accept guest authorship.

Corresponding author

Additionally, you will be asked to designate one author to act as corresponding author. Note that this is the person who will receive correspondence from the PLOS ONE editorial office, but does not need to be the person who will appear as corresponding author on the paper if accepted.

The corresponding author is responsible for ensuring that the author list and author contributions are accurate and complete. The person noted as the corresponding author should be the person who is actually responsible for ensuring that all the proper forms are submitted and accurate, and should be readily available for correspondence if PLOS ONE editors have questions or concerns.

The corresponding author must provide an ORCID iD at the time of submission by entering it in the user profile in the submission system. For more information about how to register for an ORCID iD and link it to Editorial Manager, watch this short video.

If a corresponding author will not be available for an extended period of time, please inform PLOS ONE at


Next, you’ll receive a prompt about your paper’s Section/Category. Select one of the five categories provided:

  • Medicine and public health - Research related to public health, patient care, health services, and medical specialties. 
  • Life sciences - Research in biology, physiology, botany, zoology, paleontology, microbiology, biochemistry and related areas.
  • Social sciences - Research in anthropology, archaeology, economics, political science, linguistics, human geography.
  • Neuroscience, behavioral sciences, and mental health - Research in psychology, psychiatry, neurology, human or animal behavior, and all aspects of neuroscience.
  • Physical sciences and engineering - Research in chemistry, geology, physics, astronomy, atmospheric science, oceanography, as well as any area of computer science, applied mathematics, and engineering.


This should exactly match the text of the Abstract in your manuscript file.


These will help expedite the internal processing of your manuscript. You will not have another opportunity to edit these, so please make sure to add concise, accurate keywords at this point.

Competing interests

Please declare any affiliations or relationships that could be viewed as potentially competing interests. This information will be published with the final manuscript, if accepted, so please make sure that this is accurate and as detailed as possible.

Financial disclosure

Please disclose your funders and the role they played in your manuscript. This information will be published with the final manuscript, if accepted, so please make sure that this is accurate and as detailed as possible.

Please include relevant grant numbers and the URL of any funder’s website. Please also state whether any individuals employed or contracted by the funders (other than the named authors) played any role in: study design, data collection and analysis, decision to publish, or preparation of the manuscript. If so, please name the individual and describe their role. If no individuals employed or contracted by the funder(s), other than the authors, were involved in these tasks and the authors had unrestricted access to the data, please state, “The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.”

Ethics statement

You must provide an ethics statement if your study made use of human or vertebrate animal subjects and/or tissue. The text in this field should exactly match the text of the ethics statement in the body of your paper; we recommend that you cut and paste your paper’s ethics statement into this field. The information submitted here will be evaluated by the PLOS ONE editors to ensure that it meets our standards, so please include as much information as possible. See the PLOS ONE Criteria for Publication for more information about ethics requirements.

Previous interactions

If you are submitting your manuscript following a recommendation from another PLOS journal, or if you have had a previous interaction with PLOS ONE about the manuscript or closely related manuscripts, please indicate the extent of your previous interaction here.

Suggest Academic Editors

Please recommend 2-5 Academic Editors from our board who you feel are qualified to handle your submission based on their areas of expertise.

Collections submission

Please indicate if you are submitting your paper as a part of a collection. Read more information about PLOS Collections.

New taxon 

If your paper describes a new taxon, please give its name. Read the guidelines for describing a new taxon.

Dual publications

Please explain whether any of the elements of your paper have ever been published anywhere before. If so, we may have to consider copyright issues, so it is very important that you provide this information in full.

US Government employee

If you are an employee of the US Government, please indicate that here.

Author contributions

This is a series of questions that will enable you to state the contributions of each author. Each author listed on the manuscript should have made a real and concrete contribution to the submission, and each person who contributed to the manuscript should be listed. More information about authorship can be found in the Editorial Policies.

Required statements

Next you must enter your initials to indicate your agreement with four required statements regarding PLOS Editorial and Publishing Policies.

Direct billing to institutions and funders

If your institution has a direct billing relationship with PLOS, please indicate this here.

Publication fees

Select the country that provided the primary funding for the research in the submission. 

Publication fees are US$1595 per manuscript and will be billed upon acceptance. Editors and reviewers have no access to payment information, therefore inability to pay does not influence the decision to publish a paper.

Read more about publication fees and publication fee support.

For questions about publication fees, you must contact the Author Billing department. Do not email the journal about publication fees.

Group authors and consortia

If your author list includes a group author or consortium, enter its name in the free text box.


Specify whether your manuscript is currently posted on a preprint server. If so, provide the DOI or identifier.

If your submission describes primary research in the life sciences and has not already been posted as a preprint, you may opt-in to have it posted to the bioRxiv preprint server concurrent with your submission to PLOS ONE.

If you choose to post your manuscript to bioRxiv, select the article category and subject from the dropdown lists provided.

Enter comments

You may enter comments for the editorial office here.

Oppose reviewers

If there are people you think should not be invited to review your paper, please provide their information here, as well as the reason for opposition. If there are any Academic Editors you think should not be invited to review your paper, please also provide their information here, making clear that they are an editor, not a reviewer. You must also provide an explanation for your opposition.  The editorial team will respect these requests so long as this does not interfere with the objective and thorough assessment of the submission. 

Attach files

Now you will upload your cover letter and each of the files to be included in your manuscript. For each file you upload to the system, you will select the file type from the “Item” dropdown menu. Enter or amend the autofill description for each file in the Description box. When you are done uploading files, you will have an opportunity to review your file inventory before finalizing your submission.

Review file inventory

When you are satisfied, click “Next” at the bottom of this page. If you experience any issues with your figures, please use the PACE tool to assess them. Watch this short video for instructions about using PACE. 

Create a PDF

In this step, the system will merge all of your files into a PDF for your approval. When you are ready, approve the PDF to finalize your submission.

Revised Manuscripts

Are you submitting a revision? Read the guidelines for revised manuscripts.


Please contact if you have any questions.

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