PONE-D-22-05054Analysing the impact of modifiable risk factors on cardiovascular diseases mortality in BrazilPLOS ONE

Dear Dr. Gaspar,

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Venkata Naga Srikanth Garikipati, PhD

Academic Editor

PLOS ONE

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Reviewer #1: Yes

Reviewer #2: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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5. Review Comments to the Author

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Reviewer #1: Authors have examined the impact of changes in modifiable risk factors on CVD mortality in 26 Brazilian states from 2005 to 2017. As the results, authors have found Reduction in smoking was the risk factor that led to the prevention of highest number of CVD deaths, while hyperglycemia showed the most deleterious

association with CVD death. Manuscript is well written and results are very important.

However, It would be interesting to know what are the cancer incidence rate among these CVD patients and their deaths and how the cancer and its therapy impact the CVD deaths.

Reviewer #2: The authors described the correlation between hyperglycaemia and CVD with disparities among different population gender groups in Brazil. It is interesting to note that women are more prone to diabetes and hyperglycaemia induced CVD than men. The study “Analysing the impact of modifiable risk factors on cardiovascular diseases mortality in Brazil" is a lucid read and the data presented through masses of statistics in the current research sets tone for the future directives with regard to CVD management in population in Brazil.

There are certain typographical errors in the writing which authors should improve.

With regard to availability of the data sharing of this research, it would be better if details where and how the data can be accessed and reused would be good.

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Reviewer #1: No

Reviewer #2: No

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Analysing the impact of modifiable risk factors on cardiovascular diseases mortality in Brazil

PONE-D-22-05054R1

Dear Dr. Gaspar

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

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Kind regards,

Venkata Naga Srikanth Garikipati, PhD

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments: