PONE-D-21-37123Predictors of rapid eye movement sleep behavior disorder in patients with Parkinson's disease based on random forest and decision treePLOS ONE

Dear Dr. Xu,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

The paper definitely needs English editing. Focus should also be made on using the same abbreviations everywhere in text (for example for PD without RBD: NO P-RBD, NP-RBD, PD-NRBD, PD-nRBD; which abbreviation should be used?)

References should be included everywhere in text, where needed (for example the rating scales for motor and nonmotor symptoms in Materials and Methods)

In Materials and Methods it is mentioned: ‘A total of 102 patients with Parkinson's disease who were admitted to…’and in the rest of the paper 169 patients are mentioned. What do the 102 represent?

The conclusions should be rephrased and presented more clearly in relation to the results.

Please submit your revised manuscript by Mar 19 2022 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org. When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.

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Reviewer Comments:

Review Comments to the Author:

Reviewer #1:

The paper focuses on RBD in Patients with Parkinson’s Disease, especially in finding predicting factors for the development of RBD in PD Patients. It is an important issue, since RBD can be considered a preclinical marker for neurodegeneration and it has already been showed that PD patients with RBD have more severe motor and cognitive symptoms.

The authors compare three statistical methods for evaluating predictors for RBD in PD Patients. The statistical methods are extensively explained.

The paper can be published after some revisions.

The paper definitely needs English editing. Focus should also be made on using the same abbreviations everywhere in text (for example for PD without RBD: NO P-RBD, NP-RBD, PD-NRBD, PD-nRBD; which abbreviation should be used?)

References should be included everywhere in text, where needed (for example the rating scales for motor and nonmotor symptoms in Materials and Methods)

In Materials and Methods it is mentioned: ‘A total of 102 patients with Parkinson's disease who were admitted to…’and in the rest of the paper 169 patients are mentioned. What do the 102 represent?

The conclusions should be rephrased and presented more clearly in relation to the results.

PONE-D-21-37123R1Predictors of rapid eye movement sleep behavior disorder in patients with Parkinson's disease based on random forest and decision treePLOS ONE

Dear Dr. xu,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process (please find in the attached file.

Please submit your revised manuscript by May 14 2022 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org. When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.

Please include the following items when submitting your revised manuscript:

• A rebuttal letter that responds to each point raised by the academic editor and reviewer(s). You should upload this letter as a separate file labeled 'Response to Reviewers'.
• A marked-up copy of your manuscript that highlights changes made to the original version. You should upload this as a separate file labeled 'Revised Manuscript with Track Changes'.
• An unmarked version of your revised paper without tracked changes. You should upload this as a separate file labeled 'Manuscript'.

If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter. Guidelines for resubmitting your figure files are available below the reviewer comments at the end of this letter.

If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. For instructions see: https://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols. Additionally, PLOS ONE offers an option for publishing peer-reviewed Lab Protocol articles, which describe protocols hosted on protocols.io. Read more information on sharing protocols at https://plos.org/protocols?utm_medium=editorial-email&utm_source=authorletters&utm_campaign=protocols.

We look forward to receiving your revised manuscript.

Kind regards,

Federica Provini

Academic Editor

PLOS ONE

Journal Requirements:

Please review your reference list to ensure that it is complete and correct. If you have cited papers that have been retracted, please include the rationale for doing so in the manuscript text, or remove these references and replace them with relevant current references. Any changes to the reference list should be mentioned in the rebuttal letter that accompanies your revised manuscript. If you need to cite a retracted article, indicate the article’s retracted status in the References list and also include a citation and full reference for the retraction notice.

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

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Reviewer #1: All comments have been addressed

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Reviewer #1: Yes

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3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

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Reviewer #1: Yes

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Reviewer #1: Yes

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6. Review Comments to the Author

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Reviewer #1: Thank you for answering all the questions. Some minimal writing improvements are needed (marked with yellow in the PDF file). Otherwise no further changes needed.

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Reviewer #1: No

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Attachments

Attachment

Submitted filename: LM PONE-D-21-37123_R1.pdf

Predictors of rapid eye movement sleep behavior disorder in patients with Parkinson's disease based on random forest and decision tree

PONE-D-21-37123R2

Dear Dr. Xu,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

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Kind regards,

Federica Provini

Academic Editor

PLOS ONE