PONE-D-19-34745

Predictive Value of Cystatin C and Neutrophil Gelatinase-associated Lipocalin in Contrast-induced Nephropathy: A Systematic Review and Meta-analysis

PLOS ONE

Dear Dr Chen,

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

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3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: Page 3 line 58, please select decisions or interventions, not both.

Page 4 line 67. I suggest to add: "and catabolized by the tubular cells".

Page 4 lines 81 and 82. Systematic instead systemic.

Page 5 line 97, the same in the title of Table 1.

Page 6 line 120, pleaspaid atention to the wording.

Page 6 line 122, in "patient characteristic" comorbidities are not mentioned being relevant in CIN. However, were included in the analysis. Please correct this inconsistency.

Page 12 Table 3. Paid atention to table design. When name and last name of first author were included the line is double but stays single in the remaining columns.

Page 19 line 307, I found confusing the sentence "After kidney injury, the rise in serum cystatin C levels can be used to detect even a minor glomerular filtration rate (GFR) reduction". Please clarify.

Page 22 line 362, ESUR definition and AKIN definition are mixed. Relative increase of SCr and time limit are crossed.

There are many references there in plain text. Please check for abbreviations.

Reviewer #2: The systematic review and meta-analysis performed by Yi et al addresses an important and practical issue, i.e, the diagnostic performance of renal biomarkers, NGAL AND CYSTATIN C, in contrast induced nephropathy. A careful and detailed statistical analysis was performed pertaining the appropriate literature published until november 2019. They concluded that both NGal and especially Cystatin C, may serve as early diagnostic indicators of CIN.

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Reviewer #1: Yes: Raúl Lombardi

Reviewer #2: No

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Predictive value of cystatin C and neutrophil gelatinase-associated lipocalin in contrast-induced nephropathy: a systematic review and meta-analysis

PONE-D-19-34745R1

Dear Dr. Chen,

We are pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it complies with all outstanding technical requirements.

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With kind regards,

Emmanuel A Burdmann

Section Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

**********

3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

**********

5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

**********

6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: (No Response)

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7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: Yes: Raul Lombardi