Incidence and predictors of HIV related opportunistic infections after initiation of highly active antiretroviral therapy at Ayder Referral Hospital, Mekelle, Ethiopia: a retrospective single centered cohort study

PONE-D-19-24196

Dear Dr. Zekarias

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Yatin N. Dholakia, MD

Academic Editor

PLOS ONE

Additional Editor Comments:

New guidelines for managing HIV infection recommend initiating ART as soon as one is diagnosed to have been infected.

The findings presented in the study may therefore have no relevance in the recent times, however they are interesting and may be used as baseline to any future similar study from the institution. The fact that OIs were more common in the first few months of initiating ART may be missing diagnosis before initiating ART or related to IRIS as the cases had low CD4 counts at initiation. This has been appropriately mentioned.

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Reviewer #1: Yes

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Reviewer #1: I Don't Know

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Reviewer #1: Yes

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Reviewer #1: Yes

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Reviewer #1: I find that this manuscript fulls all the criteria for publication. The only thing I would like to point out to the authors that it has been delayed for a long time. The analysis Tok place about 7 & 1/2 years back.

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Reviewer #1: No