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Table 1.

Detailed information on GWAS data.

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Fig 1.

Selection of IVs for MR.

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Fig 2.

Scatterplot of MR analysis to assess the causal relationship between mood swings and GERD.

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Fig 3.

Scatterplot of MR analysis to assess the causal relationship between highly strung and GERD.

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Fig 4.

Scatterplot of MR analysis to assess the causal relationship between anxious feelings and GERD.

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Fig 5.

Forestplot of associations between exposures and risk of GERD in MR analysis.

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Table 2.

The causal relationship between mood swings, highly strung, anxious feelings and GERD in Mendelian randomization.

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Table 2 Expand

Table 3.

Heterogeneity of mood swings, highly strung, anxious feelings and GERD in MR analysis.

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Table 3 Expand

Table 4.

Mood swings, highly strung, anxious feelings, and GERD in MR analysis of horizontal pleiotropy.

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Fig 6.

The leave-one-out method of the causal relationship between mood swings and GERD.

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Fig 6 Expand

Fig 7.

The leave-one-out method of the causal relationship between highly strung and GERD.

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Fig 7 Expand

Fig 8.

The leave-one-out method of the causal relationship between anxious feelings and GERD.

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Fig 8 Expand