Fig 1.
An overview of the analytical process.
Initially the data of 66 patients were acquired. The data of 19 patients were discarded because of the unsuitable quality of the diffusion images or unsuccessful image registration. Moreover, we identified one severe outlier in neuropsychological performance who was not included in the analysis. Overall, the data of 46 patients were analysed.
Table 1.
Description of the sample.
Fig 2.
Median Structural Connectivity (SC) matrix.
SC containing the median number of streamlines of 46 patients included in the analysis (left) and binary matrix with highlighted 5% of the strongest links (right). Each row/column represents an area of the AAL atlas (in the original order).
Fig 3.
The results of TBSS for fractional anisotropy (FA).
Blue colour scale signifies negative correlation between FA and the clinical variable, red colour scale stands for positive correlation (either positive or negative correlation is depicted per clinical scale). A: Negative correlation of FA and age. B: Positive correlation between FA and executive functions. C: Positive correlation between FA and attention. D: Positive correlation between FA and memory. Note that the correlations shown in B, C, C, did not persist (as statistically significant) after controlling for age, that was indeed detected as a significant analysis confound, see A.
Fig 4.
The relationship of age and the graph-related measures.
Scatter plots of the graph-theoretical measures computed from the structural connectivity matrices of all subjects. Subjects are visually stratified according to sex (colour) and the lesion location (marker).