Table 1.
Baseline characteristics of matcheda cohorts (main analysis).
Fig 1.
Antidepressant treatment patterns observed during the follow-up period for the TRD, non-TRD MDD, and non-MDD cohorts (main analysis).
Abbreviations: MDD = major depressive disorder; NDRI = norepinephrine-dopamine reuptake inhibitors; SSRI = selective serotonin reuptake inhibitors; SNRI = serotonin-norepinephrine reuptake inhibitors; TRD = treatment-resistant depression.
Fig 2.
All-cause HRU per-patient-per-year (main analysis)a.
A)TRD versus non-TRD MDD. B) TRD versus non-MDD. Abbreviations: CI = confidence interval; IRR = incidence rate ratio; MDD = major depressive disorder; PPPY = per patient per year. Notes: [1] HRU was measured from the index date up to two years post-index date. [2] Adjusted for baseline total healthcare costs and Quan-CCI.
Fig 3.
All-cause healthcare costs per-patient-per-yeara during the follow-up period (main analysis).
Abbreviations: CI = confidence interval; ED = emergency department; MDD = major depressive disorder; PPPY = per patient per year; TRD = treatment-resistant depression. Notes: *: significant at the 5% level. [1] Healthcare costs measured from the index date up to 2 years post-index date. [2] Adjusted for baseline total healthcare costs and Quan-CCI.
Table 2.
All-cause, behavioral health-related, and depression-related healthcare costs per-patient-per-year during the follow-up period (main analysis).