Fig 1.
The distribution of TTN truncating variants found in this study.
Bands/regions of TTN gene are shown as boxes.
Table 1.
List of TTN truncating variants identified in the study group annotated to transcript NM_001267550.2.
Table 2.
Comparison of clinical data on TTN trunc positive versus TTN trunc negative DCM probands.
Fig 2.
Kaplan-Meier cumulative survival curves for serious adverse events (SAE) (HF death, orthotopic heart transplant (OHT) or LVAD) in 72 patients with dilated cardiomyopathy, carriers of TTN truncating variants and non-carriers, p = 0.843, log-rank test = -0.198.
Table 3.
Clinical characteristics of affected and not affected TTN trunc positive relatives.
Fig 3.
Kaplan-Meier curves showing the freedom from disease for TTN trunc carriers (n = 46) for female (n = 21) and male (n = 25), p = 0.004, log-rank test = -2.91.
Fig 4.
Kaplan-Meier cumulative survival curves for SAE (HF death, OHT or LVAD) in 46 carriers of TTN truncating variants, males and females, p = 0.018, log-rank test = -2.37.