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Figure 1.

Study flow diagram.

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Figure 2.

PRISMA flow diagram.

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Table 1.

Study characteristics for inception cohorts.

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Table 2.

Methodological Quality Assessment.

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Figure 3.

Status of approved protocols for Chan 2004b study [17].

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Figure 4.

Status of approved protocols for Easterbrook 1991 study [24].

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Figure 5.

Status of approved protocols for Dickersin 1992 study [23].

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Figure 6.

Status of approved protocols for Dickersin 1993 study [3].

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Figure 7.

Status of approved protocols for Stern 1997 study [4].

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Figure 8.

Status of approved protocols for Cooper 1997 study [19].

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Figure 9.

Status of trials for Wormald 1997 study [30].

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Figure 10.

Status of approved protocols for Ioannidis 1998 study [5].

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Figure 11.

Status of approved protocols for Pich 2003 study [27].

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Figure 12.

Status of approved protocols for Cronin 2004 study [20].

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Figure 13.

Status of approved protocols for Decullier 2005 study [7].

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Figure 14.

Status of approved protocols for Decullier 2006 study [22].

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Figure 15.

Status of approved protocols for Hahn 2002 study [26].

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Figure 16.

Status of approved protocols for Chan 2004a study [18].

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Figure 17.

Status of approved protocols for Ghersi 2006 study [25].

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Figure 18.

Status of approved protocols for von Elm 2008 study [29].

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Figure 19.

Status of approved protocols for Turer 2007 study [28].

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Figure 20.

Status of approved protocols for De Jong 2010 study [21].

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Figure 21.

Status of approved protocols for Blumle 2008 study [31].

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Figure 22.

Status of approved protocols for Hall 2007 study [32].

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Table 3.

Publication and trial findings.

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Table 4.

Aspects of study level publication bias.

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Table 5.

Comparisons of primary outcome stated in protocol and in publication.

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