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High-intensity irreversible electroporation targeting intracellular structures enhance tumor ablation in lung cancer models

Fig 8

in vivo ultrastructural analysis via transmission electron microscopy.

(1 & 2) Control tissues showed intact plasma membranes, nuclear membranes, and mitochondria. (3 & 4) HEF caused severe plasma membrane rupture, pronounced nuclear membrane inflation, and mitochondrial damage. (5 & 6) LEF caused substantial plasma membrane rupture and mitochondrial damage. Arrows indicate structures: (→) plasma membrane, (→) nuclear membrane, and (>) mitochondria. Scale bars represent magnification as indicated.

Fig 8

doi: https://doi.org/10.1371/journal.pone.0346472.g008